Loss of HES1 expression is associated with extracellular matrix remodeling and tumor immune suppression in KRAS mutant colon adenocarcinomas

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The loss of HES1, a canonical Notch signaling target, may cooperate with KRAS mutations to remodel the extracellular matrix and to suppress the anti-tumor immune response. While HES1 expression is normal in benign hyperplastic polyps and normal colon tissue, HES1 expression is often lost in sessile...

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Detalles Bibliográficos
Autores principales: Wang, Lei, Gu, Wenchao, Zou, Bingqing, Kalady, Matthew, Xin, Wei, Zhou, Lan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10519992/
https://www.ncbi.nlm.nih.gov/pubmed/37749297
http://dx.doi.org/10.1038/s41598-023-42234-7

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