p70S6K/Akt dual inhibitor DIACC3010 is efficacious in preclinical models of gastric cancer alone and in combination with trastuzumab

The PI3K-Akt-mTOR (PAM) pathway is implicated in tumor progression in many tumor types, including metastatic gastric cancer (GC). The initial promise of PAM inhibitors has been unrealized in the clinic, presumably due, in part, to the up-regulation of Akt signaling that occurs when the pathway is in...

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Detalles Bibliográficos
Autores principales: Fukuoka, Shota, Koga, Yoshikatsu, Yamauchi, Mayumi, Koganemaru, Shigehiro, Yasunaga, Masahiro, Shitara, Kohei, Doi, Toshihiko, Yoshino, Takayuki, Kuronita, Toshio, Elenbaas, Brian, Wahra, Pamela, Zhang, Hong, Crowley, Lindsey, Jenkins, Molly H., Clark, Anderson, Kojima, Takashi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10520030/
https://www.ncbi.nlm.nih.gov/pubmed/37749105
http://dx.doi.org/10.1038/s41598-023-40612-9

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