A common East-Asian ALDH2 mutation causes metabolic disorders and the therapeutic effect of ALDH2 activators

Obesity and type 2 diabetes have reached pandemic proportion. ALDH2 (acetaldehyde dehydrogenase 2, mitochondrial) is the key metabolizing enzyme of acetaldehyde and other toxic aldehydes, such as 4-hydroxynonenal. A missense Glu504Lys mutation of the ALDH2 gene is prevalent in 560 million East Asian...

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Detalles Bibliográficos
Autores principales: Chang, Yi-Cheng, Lee, Hsiao-Lin, Yang, Wenjin, Hsieh, Meng-Lun, Liu, Cai-Cin, Lee, Tung-Yuan, Huang, Jing-Yong, Nong, Jiun-Yi, Li, Fu-An, Chuang, Hsiao-Li, Ding, Zhi-Zhong, Su, Wei-Lun, Chueh, Li-Yun, Tsai, Yi-Ting, Chen, Che-Hong, Mochly-Rosen, Daria, Chuang, Lee-Ming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10520061/
https://www.ncbi.nlm.nih.gov/pubmed/37749090
http://dx.doi.org/10.1038/s41467-023-41570-6

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