An original potentiating mechanism revealed by the cryo-EM structures of the human α7 nicotinic receptor in complex with nanobodies

The human α7 nicotinic receptor is a pentameric channel mediating cellular and neuronal communication. It has attracted considerable interest in designing ligands for the treatment of neurological and psychiatric disorders. To develop a novel class of α7 ligands, we recently generated two nanobodies...

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Detalles Bibliográficos
Autores principales: Prevost, Marie S., Barilone, Nathalie, Dejean de la Bâtie, Gabrielle, Pons, Stéphanie, Ayme, Gabriel, England, Patrick, Gielen, Marc, Bontems, François, Pehau-Arnaudet, Gérard, Maskos, Uwe, Lafaye, Pierre, Corringer, Pierre-Jean
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10520083/
https://www.ncbi.nlm.nih.gov/pubmed/37749098
http://dx.doi.org/10.1038/s41467-023-41734-4

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