Cargando…

Two domains of Tim50 coordinate translocation of proteins across the two mitochondrial membranes

Hundreds of mitochondrial proteins with N-terminal presequences are translocated across the outer and inner mitochondrial membranes via the TOM and TIM23 complexes, respectively. How translocation of proteins across two mitochondrial membranes is coordinated is largely unknown. Here, we show that th...

Descripción completa

Detalles Bibliográficos
Autores principales:	Genge, Marcel G, Roy Chowdhury, Shalini, Dohnálek, Vít, Yunoki, Kaori, Hirashima, Takashi, Endo, Toshiya, Doležal, Pavel, Mokranjac, Dejana
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Life Science Alliance LLC 2023
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10520260/ https://www.ncbi.nlm.nih.gov/pubmed/37748811 http://dx.doi.org/10.26508/lsa.202302122

Ejemplares similares

Coordinated Translocation of Presequence-Containing Precursor Proteins Across Two Mitochondrial Membranes: Knowns and Unknowns of How TOM and TIM23 Complexes Cooperate With Each Other
por: Genge, Marcel G., et al.
Publicado: (2022)

Tim23–Tim50 pair coordinates functions of translocators and motor proteins in mitochondrial protein import
por: Tamura, Yasushi, et al.
Publicado: (2009)

A mutagenesis analysis of Tim50, the major receptor of the TIM23 complex, identifies regions that affect its interaction with Tim23
por: Dayan, Dana, et al.
Publicado: (2019)

Role of Tim17 in coupling the import motor to the translocation channel of the mitochondrial presequence translocase
por: Demishtein-Zohary, Keren, et al.
Publicado: (2017)

Cardiolipin mediates membrane and channel interactions of the mitochondrial TIM23 protein import complex receptor Tim50
por: Malhotra, Ketan, et al.
Publicado: (2017)

Protein translocation channel of mitochondrial inner membrane and matrix-exposed import motor communicate via two-domain coupling protein
por: Banerjee, Rupa, et al.
Publicado: (2015)

Identification of Tam41 maintaining integrity of the TIM23 protein translocator complex in mitochondria
por: Tamura, Yasushi, et al.
Publicado: (2006)

Mitochondrial protein import: An unexpected disulfide bond
por: Mokranjac, Dejana
Publicado: (2016)

The structure of Tim50(164–361) suggests the mechanism by which Tim50 receives mitochondrial presequences
por: Li, Jingzhi, et al.
Publicado: (2015)

Fates of Sec, Tat, and YidC Translocases in Mitochondria and Other Eukaryotic Compartments
por: Petrů, Markéta, et al.
Publicado: (2021)

Evolution of the Tim17 protein family
por: Žárský, Vojtěch, et al.
Publicado: (2016)

Tim50a, a nuclear isoform of the mitochondrial Tim50, interacts with proteins involved in snRNP biogenesis
por: Xu, Hongzhi, et al.
Publicado: (2005)

Tim50’s presequence receptor domain is essential for signal driven transport across the TIM23 complex
por: Schulz, Christian, et al.
Publicado: (2011)

Central role of Tim17 in mitochondrial presequence protein translocation
por: Fielden, Laura F., et al.
Publicado: (2023)

Tim17 Updates: A Comprehensive Review of an Ancient Mitochondrial Protein Translocator
por: Chaudhuri, Minu, et al.
Publicado: (2020)

Two Intermembrane Space Tim Complexes Interact with Different Domains of Tim23p during Its Import into Mitochondria
por: Davis, Alison J., et al.
Publicado: (2000)

The Cross Talk between TbTim50 and PIP39, Two Aspartate-Based Protein Phosphatases, Maintains Cellular Homeostasis in Trypanosoma brucei
por: Tripathi, Anuj, et al.
Publicado: (2019)

TIM23-mediated insertion of transmembrane α-helices into the mitochondrial inner membrane
por: Botelho, Salomé Calado, et al.
Publicado: (2011)

Quality control of nonstop membrane proteins at the ER membrane and in the cytosol
por: Arakawa, Shunsuke, et al.
Publicado: (2016)

Two novel proteins in the mitochondrial outer membrane mediate β-barrel protein assembly
por: Ishikawa, Daigo, et al.
Publicado: (2004)

The Mitochondrial Protein Translocation Motor: Structural Conservation between the Human and Yeast Tim14/Pam18-Tim16/Pam16 co-Chaperones
por: Elsner, Shira, et al.
Publicado: (2009)

Role of the AAA protease Yme1 in folding of proteins in the intermembrane space of mitochondria
por: Schreiner, Bernadette, et al.
Publicado: (2012)

Diverse Functions of Tim50, a Component of the Mitochondrial Inner Membrane Protein Translocase
por: Chaudhuri, Minu, et al.
Publicado: (2021)

Mitochondrial protein import: Mia40 facilitates Tim22 translocation into the inner membrane of mitochondria
por: Wrobel, Lidia, et al.
Publicado: (2013)

One Stone, Two Birds: The Roles of Tim-3 in Acute Myeloid Leukemia
por: Wang, Zhiding, et al.
Publicado: (2021)

Long non-coding RNA Lnc-Tim3 exacerbates CD8 T cell exhaustion via binding to Tim-3 and inducing nuclear translocation of Bat3 in HCC
por: Ji, Jie, et al.
Publicado: (2018)

Mast cell activation is enhanced by Tim1:Tim4 interaction but not by Tim-1 antibodies
por: Phong, Binh, et al.
Publicado: (2016)

Erratum for Tripathi et al., “The Cross Talk between TbTim50 and PIP39, Two Aspartate-Based Protein Phosphatases, Maintains Cellular Homeostasis in Trypanosoma brucei”
por: Tripathi, Anuj, et al.
Publicado: (2019)

Tim Burton /
por: Marcos Arza, Marcos
Publicado: (2007)

Tim Lou
por: Lou, Hou Keong
Publicado: (2009)

Tim1 and Tim3 are not essential for experimental allergic asthma
por: Barlow, J L, et al.
Publicado: (2011)

The J-related Segment of Tim44 Is Essential for Cell Viability: A Mutant Tim44 Remains in the Mitochondrial Import Site, but Inefficiently Recruits mtHsp70 and Impairs Protein Translocation
por: Merlin, Alessio, et al.
Publicado: (1999)

The two-hit theory hits 50
por: Chernoff, Jonathan
Publicado: (2021)

TIM-Finder: A new method for identifying TIM-barrel proteins
por: Si, Jing-Na, et al.
Publicado: (2009)

Mertk Interacts with Tim-4 to Enhance Tim-4-Mediated Efferocytosis
por: Moon, Byeongjin, et al.
Publicado: (2020)

$^{98}_{48}Cd_{50}$- the two-proton hole spectrum in $^{100}_{50}Sn_{50}$
por: Górska, M, et al.
Publicado: (1997)

Galectin-9/TIM-3 Interaction Regulates Virus-Specific Primary and Memory CD8(+) T Cell Response
por: Sehrawat, Sharvan, et al.
Publicado: (2010)

A Single Tim Translocase in the Mitosomes of Giardia intestinalis Illustrates Convergence of Protein Import Machines in Anaerobic Eukaryotes
por: Pyrihová, Eva, et al.
Publicado: (2018)

Tim-3 Coordinates Macrophage-Trophoblast Crosstalk via Angiogenic Growth Factors to Promote Pregnancy Maintenance
por: Cui, Liyuan, et al.
Publicado: (2023)

Altered expression of Tim family molecules and an imbalanced ratio of Tim-3 to Tim-1 expression in patients with type 1 diabetes
por: Liu, Yikai, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_a47i1jtj93g4g1ugeihnbfpof6