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RBPJ Deficiency Sensitizes Pancreatic Acinar Cells to KRAS-Mediated Pancreatic Intraepithelial Neoplasia Initiation

BACKGROUND AND AIMS: Development of pancreatic ductal adenocarcinoma (PDAC) is a multistep process intensively studied; however, precocious diagnosis and effective therapy still remain unsatisfactory. The role for Notch signaling in PDAC has been discussed controversially, as both cancer-promoting a...

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Detalles Bibliográficos
Autores principales:	Pan, Leiling, Mulaw, Medhanie A., Gout, Johann, Guo, Min, Zarrin, Hina, Schwarz, Peggy, Baumann, Bernd, Seufferlein, Thomas, Wagner, Martin, Oswald, Franz
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2023
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10520364/ https://www.ncbi.nlm.nih.gov/pubmed/37543088 http://dx.doi.org/10.1016/j.jcmgh.2023.07.013

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