Mechanically sensitive HSF1 is a key regulator of left-right symmetry breaking in zebrafish embryos

The left-right symmetry breaking of vertebrate embryos requires nodal flow. However, the molecular mechanisms that mediate the asymmetric gene expression regulation under nodal flow remain elusive. Here, we report that heat shock factor 1 (HSF1) is asymmetrically activated in the Kupffer’s vesicle o...

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Detalles Bibliográficos
Autores principales: Du, Jing, Li, Shu-Kai, Guan, Liu-Yuan, Guo, Zheng, Yin, Jiang-Fan, Gao, Li, Kawanishi, Toru, Shimada, Atsuko, Zhang, Qiu-Ping, Zheng, Li-Sha, Liu, Yi-Yao, Feng, Xi-Qiao, Zhao, Lin, Chen, Dong-Yan, Takeda, Hiroyuki, Fan, Yu-Bo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10520531/
https://www.ncbi.nlm.nih.gov/pubmed/37766982
http://dx.doi.org/10.1016/j.isci.2023.107864

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