VNLG-152R and its deuterated analogs potently inhibit/repress triple/quadruple negative breast cancer of diverse racial origins in vitro and in vivo by upregulating E3 Ligase Synoviolin 1 (SYVN1) and inducing proteasomal degradation of MNK1/2

Triple-negative breast cancer (TNBC) and its recently identified subtype, quadruple negative breast cancer (QNBC), collectively account for approximately 13% of reported breast cancer cases in the United States. These aggressive forms of breast cancer are associated with poor prognoses, limited trea...

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Detalles Bibliográficos
Autores principales: Thankan, Retheesh S., Thomas, Elizabeth, Purushottamachar, Puranik, Weber, David J., Ramamurthy, Vidya P., Huang, Weiliang, Kane, Maureen A., Njar, Vincent C. O.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10520556/
https://www.ncbi.nlm.nih.gov/pubmed/37766871
http://dx.doi.org/10.3389/fonc.2023.1240996

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