Automated sulfur-[(18)F]fluoride exchange radiolabelling of a prostate specific membrane antigen (PSMA) targeted ligand using the GE FASTlab™ cassette-based platform

Sulfur-[(18)F]fluoride exchange radiochemistry is a rapid and convenient method for incorporating fluorine-18 into biologically active molecules. We report a fully automated radiolabelling procedure for the synthesis of a [(18)F]SO(3)F-bearing prostate specific membrane antigen (PSMA) targeted ligan...

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Autores principales: Yang, Zixuan, Barnes, Chris, Domarkas, Juozas, Koch-Paszkowski, Joanna, Wright, John, Amgheib, Ala, Renard, Isaline, Fu, Ruisi, Archibald, Stephen, Aboagye, Eric O., Allott, Louis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2023
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10520611/
https://www.ncbi.nlm.nih.gov/pubmed/38013985
http://dx.doi.org/10.1039/d3re00307h
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author Yang, Zixuan
Barnes, Chris
Domarkas, Juozas
Koch-Paszkowski, Joanna
Wright, John
Amgheib, Ala
Renard, Isaline
Fu, Ruisi
Archibald, Stephen
Aboagye, Eric O.
Allott, Louis
author_facet Yang, Zixuan
Barnes, Chris
Domarkas, Juozas
Koch-Paszkowski, Joanna
Wright, John
Amgheib, Ala
Renard, Isaline
Fu, Ruisi
Archibald, Stephen
Aboagye, Eric O.
Allott, Louis
author_sort Yang, Zixuan
collection PubMed
description Sulfur-[(18)F]fluoride exchange radiochemistry is a rapid and convenient method for incorporating fluorine-18 into biologically active molecules. We report a fully automated radiolabelling procedure for the synthesis of a [(18)F]SO(3)F-bearing prostate specific membrane antigen (PSMA) targeted ligand ([(18)F]5) using the GE FASTLab™ cassette-based platform in a 25.0 ± 2.6% radiochemical yield (decay corrected). Uptake in vitro and in vivo correlated with PSMA expression, and the radioligand exhibited favourable biodistribution and pharmacokinetic profiles.
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spelling pubmed-105206112023-09-27 Automated sulfur-[(18)F]fluoride exchange radiolabelling of a prostate specific membrane antigen (PSMA) targeted ligand using the GE FASTlab™ cassette-based platform Yang, Zixuan Barnes, Chris Domarkas, Juozas Koch-Paszkowski, Joanna Wright, John Amgheib, Ala Renard, Isaline Fu, Ruisi Archibald, Stephen Aboagye, Eric O. Allott, Louis React Chem Eng Chemistry Sulfur-[(18)F]fluoride exchange radiochemistry is a rapid and convenient method for incorporating fluorine-18 into biologically active molecules. We report a fully automated radiolabelling procedure for the synthesis of a [(18)F]SO(3)F-bearing prostate specific membrane antigen (PSMA) targeted ligand ([(18)F]5) using the GE FASTLab™ cassette-based platform in a 25.0 ± 2.6% radiochemical yield (decay corrected). Uptake in vitro and in vivo correlated with PSMA expression, and the radioligand exhibited favourable biodistribution and pharmacokinetic profiles. The Royal Society of Chemistry 2023-08-21 /pmc/articles/PMC10520611/ /pubmed/38013985 http://dx.doi.org/10.1039/d3re00307h Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by/3.0/
spellingShingle Chemistry
Yang, Zixuan
Barnes, Chris
Domarkas, Juozas
Koch-Paszkowski, Joanna
Wright, John
Amgheib, Ala
Renard, Isaline
Fu, Ruisi
Archibald, Stephen
Aboagye, Eric O.
Allott, Louis
Automated sulfur-[(18)F]fluoride exchange radiolabelling of a prostate specific membrane antigen (PSMA) targeted ligand using the GE FASTlab™ cassette-based platform
title Automated sulfur-[(18)F]fluoride exchange radiolabelling of a prostate specific membrane antigen (PSMA) targeted ligand using the GE FASTlab™ cassette-based platform
title_full Automated sulfur-[(18)F]fluoride exchange radiolabelling of a prostate specific membrane antigen (PSMA) targeted ligand using the GE FASTlab™ cassette-based platform
title_fullStr Automated sulfur-[(18)F]fluoride exchange radiolabelling of a prostate specific membrane antigen (PSMA) targeted ligand using the GE FASTlab™ cassette-based platform
title_full_unstemmed Automated sulfur-[(18)F]fluoride exchange radiolabelling of a prostate specific membrane antigen (PSMA) targeted ligand using the GE FASTlab™ cassette-based platform
title_short Automated sulfur-[(18)F]fluoride exchange radiolabelling of a prostate specific membrane antigen (PSMA) targeted ligand using the GE FASTlab™ cassette-based platform
title_sort automated sulfur-[(18)f]fluoride exchange radiolabelling of a prostate specific membrane antigen (psma) targeted ligand using the ge fastlab™ cassette-based platform
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10520611/
https://www.ncbi.nlm.nih.gov/pubmed/38013985
http://dx.doi.org/10.1039/d3re00307h
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