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The Oxysterol Receptor EBI2 Links Innate and Adaptive Immunity to Limit IFN Response and Systemic Lupus Erythematosus (Adv. Sci. 27/2023)
Systemic Lupus Erythematosus In article number 2207108, Nan Shen, Hongyan Wang, Bin Wei, and co‐workers report elevated plasma levels of 7α,25‐dihydroxycholesterol, but its receptor EBI2 is reduced in monocyte/macrophages from patients and mice with systemic lupus erythematosus (SLE). EBI2‐deficient...
| Autores principales: | , , , , , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
John Wiley and Sons Inc.
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10520647/ http://dx.doi.org/10.1002/advs.202370181 |
| _version_ | 1785109966400520192 |
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| author | Zhang, Fang Zhang, Baokai Ding, Huihua Li, Xiangyue Wang, Xilin Zhang, Xiaomin Liu, Qiaojie Feng, Qiuyun Han, Mingshun Chen, Longlong Qi, Linlin Yang, Dan Li, Xiaojing Zhu, Xingguo Zhao, Qi Qiu, Jiaqian Zhu, Zhengjiang Tang, Huiru Shen, Nan Wang, Hongyan Wei, Bin |
| author_facet | Zhang, Fang Zhang, Baokai Ding, Huihua Li, Xiangyue Wang, Xilin Zhang, Xiaomin Liu, Qiaojie Feng, Qiuyun Han, Mingshun Chen, Longlong Qi, Linlin Yang, Dan Li, Xiaojing Zhu, Xingguo Zhao, Qi Qiu, Jiaqian Zhu, Zhengjiang Tang, Huiru Shen, Nan Wang, Hongyan Wei, Bin |
| author_sort | Zhang, Fang |
| collection | PubMed |
| description | Systemic Lupus Erythematosus In article number 2207108, Nan Shen, Hongyan Wang, Bin Wei, and co‐workers report elevated plasma levels of 7α,25‐dihydroxycholesterol, but its receptor EBI2 is reduced in monocyte/macrophages from patients and mice with systemic lupus erythematosus (SLE). EBI2‐deficient macrophages produce higher levels of IFN‐I, chemokines and cytokines, which further recruits and activates T and B lymphocytes to exacerbate the development of SLE. [Image: see text] |
| format | Online Article Text |
| id | pubmed-10520647 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2023 |
| publisher | John Wiley and Sons Inc. |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-105206472023-09-27 The Oxysterol Receptor EBI2 Links Innate and Adaptive Immunity to Limit IFN Response and Systemic Lupus Erythematosus (Adv. Sci. 27/2023) Zhang, Fang Zhang, Baokai Ding, Huihua Li, Xiangyue Wang, Xilin Zhang, Xiaomin Liu, Qiaojie Feng, Qiuyun Han, Mingshun Chen, Longlong Qi, Linlin Yang, Dan Li, Xiaojing Zhu, Xingguo Zhao, Qi Qiu, Jiaqian Zhu, Zhengjiang Tang, Huiru Shen, Nan Wang, Hongyan Wei, Bin Adv Sci (Weinh) Inside Front Cover Systemic Lupus Erythematosus In article number 2207108, Nan Shen, Hongyan Wang, Bin Wei, and co‐workers report elevated plasma levels of 7α,25‐dihydroxycholesterol, but its receptor EBI2 is reduced in monocyte/macrophages from patients and mice with systemic lupus erythematosus (SLE). EBI2‐deficient macrophages produce higher levels of IFN‐I, chemokines and cytokines, which further recruits and activates T and B lymphocytes to exacerbate the development of SLE. [Image: see text] John Wiley and Sons Inc. 2023-09-26 /pmc/articles/PMC10520647/ http://dx.doi.org/10.1002/advs.202370181 Text en © 2023 Wiley‐VCH GmbH https://creativecommons.org/licenses/by-nc/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. |
| spellingShingle | Inside Front Cover Zhang, Fang Zhang, Baokai Ding, Huihua Li, Xiangyue Wang, Xilin Zhang, Xiaomin Liu, Qiaojie Feng, Qiuyun Han, Mingshun Chen, Longlong Qi, Linlin Yang, Dan Li, Xiaojing Zhu, Xingguo Zhao, Qi Qiu, Jiaqian Zhu, Zhengjiang Tang, Huiru Shen, Nan Wang, Hongyan Wei, Bin The Oxysterol Receptor EBI2 Links Innate and Adaptive Immunity to Limit IFN Response and Systemic Lupus Erythematosus (Adv. Sci. 27/2023) |
| title | The Oxysterol Receptor EBI2 Links Innate and Adaptive Immunity to Limit IFN Response and Systemic Lupus Erythematosus (Adv. Sci. 27/2023) |
| title_full | The Oxysterol Receptor EBI2 Links Innate and Adaptive Immunity to Limit IFN Response and Systemic Lupus Erythematosus (Adv. Sci. 27/2023) |
| title_fullStr | The Oxysterol Receptor EBI2 Links Innate and Adaptive Immunity to Limit IFN Response and Systemic Lupus Erythematosus (Adv. Sci. 27/2023) |
| title_full_unstemmed | The Oxysterol Receptor EBI2 Links Innate and Adaptive Immunity to Limit IFN Response and Systemic Lupus Erythematosus (Adv. Sci. 27/2023) |
| title_short | The Oxysterol Receptor EBI2 Links Innate and Adaptive Immunity to Limit IFN Response and Systemic Lupus Erythematosus (Adv. Sci. 27/2023) |
| title_sort | oxysterol receptor ebi2 links innate and adaptive immunity to limit ifn response and systemic lupus erythematosus (adv. sci. 27/2023) |
| topic | Inside Front Cover |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10520647/ http://dx.doi.org/10.1002/advs.202370181 |
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