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Targeting Squalene Epoxidase Confers Metabolic Vulnerability and Overcomes Chemoresistance in HNSCC

Cisplatin resistance poses a substantial hurdle in effectively treating head and neck squamous cell carcinoma (HNSCC). Utilizing multiple tumor models and examining an internal HNSCC cohort, squalene epoxidase (SQLE) is pinpointed as a key driver of chemoresistance and tumorigenesis, operating throu...

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Detalles Bibliográficos
Autores principales:	Zhao, Xinyuan, Guo, Bing, Sun, Wenjuan, Yu, Jinhua, Cui, Li
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2023
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10520660/ https://www.ncbi.nlm.nih.gov/pubmed/37490552 http://dx.doi.org/10.1002/advs.202206878

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