EGFR‐Induced and c‐Src‐Mediated CD47 Phosphorylation Inhibits TRIM21‐Dependent Polyubiquitylation and Degradation of CD47 to Promote Tumor Immune Evasion

Tumor cells often overexpress immune checkpoint proteins, including CD47, for immune evasion. However, whether or how oncogenic activation of receptor tyrosine kinases, which are crucial drivers in tumor development, regulates CD47 expression is unknown. Here, it is demonstrated that epidermal growt...

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Detalles Bibliográficos
Autores principales: Du, Linyong, Su, Zhipeng, Wang, Silu, Meng, Ying, Xiao, Fei, Xu, Daqian, Li, Xinjian, Qian, Xu, Lee, Su Bin, Lee, Jong‐Ho, Lu, Zhimin, Lyu, Jianxin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10520678/
https://www.ncbi.nlm.nih.gov/pubmed/37541303
http://dx.doi.org/10.1002/advs.202206380

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