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Exosomal non-coding RNAs: Blueprint in colorectal cancer metastasis and therapeutic targets

Colorectal cancer (CRC) is ranked as the world's third-most prevalent cancer, and metastatic CRC considerably increases cancer-related fatalities globally. A number of complex mechanisms that are strictly controlled at the molecular level are involved in metastasis, which is the primary reason...

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Autores principales: Hussen, Bashdar Mahmud, Abdullah, Sara Tharwat, Abdullah, Snur Rasool, Younis, Yousif Mohammed, Hidayat, Hazha Jamal, Rasul, Mohammed Fatih, Mohamadtahr, Sayran
Formato: Online Artículo Texto
Lenguaje:English
Publicado: KeAi Publishing 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10520679/
https://www.ncbi.nlm.nih.gov/pubmed/37767111
http://dx.doi.org/10.1016/j.ncrna.2023.09.001
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author Hussen, Bashdar Mahmud
Abdullah, Sara Tharwat
Abdullah, Snur Rasool
Younis, Yousif Mohammed
Hidayat, Hazha Jamal
Rasul, Mohammed Fatih
Mohamadtahr, Sayran
author_facet Hussen, Bashdar Mahmud
Abdullah, Sara Tharwat
Abdullah, Snur Rasool
Younis, Yousif Mohammed
Hidayat, Hazha Jamal
Rasul, Mohammed Fatih
Mohamadtahr, Sayran
author_sort Hussen, Bashdar Mahmud
collection PubMed
description Colorectal cancer (CRC) is ranked as the world's third-most prevalent cancer, and metastatic CRC considerably increases cancer-related fatalities globally. A number of complex mechanisms that are strictly controlled at the molecular level are involved in metastasis, which is the primary reason for death in people with CRC. Recently, it has become clear that exosomes, which are small extracellular vesicles released by non-tumorous and tumorigenic cells, play a critical role as communication mediators among tumor microenvironment (TME). To facilitate communication between the TME and cancer cells, non-coding RNAs (ncRNAs) play a crucial role and are recognized as potent regulators of gene expression and cellular processes, such as metastasis and drug resistance. NcRNAs are now recognized as potent regulators of gene expression and many hallmarks of cancer, including metastasis. Exosomal ncRNAs, like miRNAs, circRNAs, and lncRNAs, have been demonstrated to influence a number of cellular mechanisms that contribute to CRC metastasis. However, the molecular mechanisms that link exosomal ncRNAs with CRC metastasis are not well understood. This review highlights the essential roles that exosomal ncRNAs play in the progression of CRC metastatic disease and explores the therapeutic choices that are open to patients who have CRC metastases. However, exosomal ncRNA treatment strategy development is still in its early phases; consequently, additional investigation is required to improve delivery methods and find novel therapeutic targets as well as confirm the effectiveness and safety of these therapies in preclinical and clinical contexts.
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spelling pubmed-105206792023-09-27 Exosomal non-coding RNAs: Blueprint in colorectal cancer metastasis and therapeutic targets Hussen, Bashdar Mahmud Abdullah, Sara Tharwat Abdullah, Snur Rasool Younis, Yousif Mohammed Hidayat, Hazha Jamal Rasul, Mohammed Fatih Mohamadtahr, Sayran Noncoding RNA Res Review Article Colorectal cancer (CRC) is ranked as the world's third-most prevalent cancer, and metastatic CRC considerably increases cancer-related fatalities globally. A number of complex mechanisms that are strictly controlled at the molecular level are involved in metastasis, which is the primary reason for death in people with CRC. Recently, it has become clear that exosomes, which are small extracellular vesicles released by non-tumorous and tumorigenic cells, play a critical role as communication mediators among tumor microenvironment (TME). To facilitate communication between the TME and cancer cells, non-coding RNAs (ncRNAs) play a crucial role and are recognized as potent regulators of gene expression and cellular processes, such as metastasis and drug resistance. NcRNAs are now recognized as potent regulators of gene expression and many hallmarks of cancer, including metastasis. Exosomal ncRNAs, like miRNAs, circRNAs, and lncRNAs, have been demonstrated to influence a number of cellular mechanisms that contribute to CRC metastasis. However, the molecular mechanisms that link exosomal ncRNAs with CRC metastasis are not well understood. This review highlights the essential roles that exosomal ncRNAs play in the progression of CRC metastatic disease and explores the therapeutic choices that are open to patients who have CRC metastases. However, exosomal ncRNA treatment strategy development is still in its early phases; consequently, additional investigation is required to improve delivery methods and find novel therapeutic targets as well as confirm the effectiveness and safety of these therapies in preclinical and clinical contexts. KeAi Publishing 2023-09-11 /pmc/articles/PMC10520679/ /pubmed/37767111 http://dx.doi.org/10.1016/j.ncrna.2023.09.001 Text en © 2023 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Review Article
Hussen, Bashdar Mahmud
Abdullah, Sara Tharwat
Abdullah, Snur Rasool
Younis, Yousif Mohammed
Hidayat, Hazha Jamal
Rasul, Mohammed Fatih
Mohamadtahr, Sayran
Exosomal non-coding RNAs: Blueprint in colorectal cancer metastasis and therapeutic targets
title Exosomal non-coding RNAs: Blueprint in colorectal cancer metastasis and therapeutic targets
title_full Exosomal non-coding RNAs: Blueprint in colorectal cancer metastasis and therapeutic targets
title_fullStr Exosomal non-coding RNAs: Blueprint in colorectal cancer metastasis and therapeutic targets
title_full_unstemmed Exosomal non-coding RNAs: Blueprint in colorectal cancer metastasis and therapeutic targets
title_short Exosomal non-coding RNAs: Blueprint in colorectal cancer metastasis and therapeutic targets
title_sort exosomal non-coding rnas: blueprint in colorectal cancer metastasis and therapeutic targets
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10520679/
https://www.ncbi.nlm.nih.gov/pubmed/37767111
http://dx.doi.org/10.1016/j.ncrna.2023.09.001
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