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Exosomal non-coding RNAs: Blueprint in colorectal cancer metastasis and therapeutic targets
Colorectal cancer (CRC) is ranked as the world's third-most prevalent cancer, and metastatic CRC considerably increases cancer-related fatalities globally. A number of complex mechanisms that are strictly controlled at the molecular level are involved in metastasis, which is the primary reason...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
KeAi Publishing
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10520679/ https://www.ncbi.nlm.nih.gov/pubmed/37767111 http://dx.doi.org/10.1016/j.ncrna.2023.09.001 |
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author | Hussen, Bashdar Mahmud Abdullah, Sara Tharwat Abdullah, Snur Rasool Younis, Yousif Mohammed Hidayat, Hazha Jamal Rasul, Mohammed Fatih Mohamadtahr, Sayran |
author_facet | Hussen, Bashdar Mahmud Abdullah, Sara Tharwat Abdullah, Snur Rasool Younis, Yousif Mohammed Hidayat, Hazha Jamal Rasul, Mohammed Fatih Mohamadtahr, Sayran |
author_sort | Hussen, Bashdar Mahmud |
collection | PubMed |
description | Colorectal cancer (CRC) is ranked as the world's third-most prevalent cancer, and metastatic CRC considerably increases cancer-related fatalities globally. A number of complex mechanisms that are strictly controlled at the molecular level are involved in metastasis, which is the primary reason for death in people with CRC. Recently, it has become clear that exosomes, which are small extracellular vesicles released by non-tumorous and tumorigenic cells, play a critical role as communication mediators among tumor microenvironment (TME). To facilitate communication between the TME and cancer cells, non-coding RNAs (ncRNAs) play a crucial role and are recognized as potent regulators of gene expression and cellular processes, such as metastasis and drug resistance. NcRNAs are now recognized as potent regulators of gene expression and many hallmarks of cancer, including metastasis. Exosomal ncRNAs, like miRNAs, circRNAs, and lncRNAs, have been demonstrated to influence a number of cellular mechanisms that contribute to CRC metastasis. However, the molecular mechanisms that link exosomal ncRNAs with CRC metastasis are not well understood. This review highlights the essential roles that exosomal ncRNAs play in the progression of CRC metastatic disease and explores the therapeutic choices that are open to patients who have CRC metastases. However, exosomal ncRNA treatment strategy development is still in its early phases; consequently, additional investigation is required to improve delivery methods and find novel therapeutic targets as well as confirm the effectiveness and safety of these therapies in preclinical and clinical contexts. |
format | Online Article Text |
id | pubmed-10520679 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | KeAi Publishing |
record_format | MEDLINE/PubMed |
spelling | pubmed-105206792023-09-27 Exosomal non-coding RNAs: Blueprint in colorectal cancer metastasis and therapeutic targets Hussen, Bashdar Mahmud Abdullah, Sara Tharwat Abdullah, Snur Rasool Younis, Yousif Mohammed Hidayat, Hazha Jamal Rasul, Mohammed Fatih Mohamadtahr, Sayran Noncoding RNA Res Review Article Colorectal cancer (CRC) is ranked as the world's third-most prevalent cancer, and metastatic CRC considerably increases cancer-related fatalities globally. A number of complex mechanisms that are strictly controlled at the molecular level are involved in metastasis, which is the primary reason for death in people with CRC. Recently, it has become clear that exosomes, which are small extracellular vesicles released by non-tumorous and tumorigenic cells, play a critical role as communication mediators among tumor microenvironment (TME). To facilitate communication between the TME and cancer cells, non-coding RNAs (ncRNAs) play a crucial role and are recognized as potent regulators of gene expression and cellular processes, such as metastasis and drug resistance. NcRNAs are now recognized as potent regulators of gene expression and many hallmarks of cancer, including metastasis. Exosomal ncRNAs, like miRNAs, circRNAs, and lncRNAs, have been demonstrated to influence a number of cellular mechanisms that contribute to CRC metastasis. However, the molecular mechanisms that link exosomal ncRNAs with CRC metastasis are not well understood. This review highlights the essential roles that exosomal ncRNAs play in the progression of CRC metastatic disease and explores the therapeutic choices that are open to patients who have CRC metastases. However, exosomal ncRNA treatment strategy development is still in its early phases; consequently, additional investigation is required to improve delivery methods and find novel therapeutic targets as well as confirm the effectiveness and safety of these therapies in preclinical and clinical contexts. KeAi Publishing 2023-09-11 /pmc/articles/PMC10520679/ /pubmed/37767111 http://dx.doi.org/10.1016/j.ncrna.2023.09.001 Text en © 2023 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Review Article Hussen, Bashdar Mahmud Abdullah, Sara Tharwat Abdullah, Snur Rasool Younis, Yousif Mohammed Hidayat, Hazha Jamal Rasul, Mohammed Fatih Mohamadtahr, Sayran Exosomal non-coding RNAs: Blueprint in colorectal cancer metastasis and therapeutic targets |
title | Exosomal non-coding RNAs: Blueprint in colorectal cancer metastasis and therapeutic targets |
title_full | Exosomal non-coding RNAs: Blueprint in colorectal cancer metastasis and therapeutic targets |
title_fullStr | Exosomal non-coding RNAs: Blueprint in colorectal cancer metastasis and therapeutic targets |
title_full_unstemmed | Exosomal non-coding RNAs: Blueprint in colorectal cancer metastasis and therapeutic targets |
title_short | Exosomal non-coding RNAs: Blueprint in colorectal cancer metastasis and therapeutic targets |
title_sort | exosomal non-coding rnas: blueprint in colorectal cancer metastasis and therapeutic targets |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10520679/ https://www.ncbi.nlm.nih.gov/pubmed/37767111 http://dx.doi.org/10.1016/j.ncrna.2023.09.001 |
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