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Literature review on hepatoprotective effects of diosgenin: possible mechanisms of action
Liver diseases are among the major causes of death worldwide. Alcohol consumption, obesity, diabetes mellitus, viral infection, and drug-induced liver injury are common risk factors for the development of liver diseases. Diosgenin is a herbal steroidal sapogenin with hepatoprotective properties. Thi...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10520708/ https://www.ncbi.nlm.nih.gov/pubmed/37767400 http://dx.doi.org/10.3389/fphar.2023.1226548 |
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author | Mohseni-Moghaddam, Parvaneh Khanmohammadi, Manijeh Roghani, Mehrdad |
author_facet | Mohseni-Moghaddam, Parvaneh Khanmohammadi, Manijeh Roghani, Mehrdad |
author_sort | Mohseni-Moghaddam, Parvaneh |
collection | PubMed |
description | Liver diseases are among the major causes of death worldwide. Alcohol consumption, obesity, diabetes mellitus, viral infection, and drug-induced liver injury are common risk factors for the development of liver diseases. Diosgenin is a herbal steroidal sapogenin with hepatoprotective properties. This phytosteroid modulates lipid profile and prevents liver injury and fibrosis, metabolic associated fatty liver disease (MAFLD), steatohepatitis, and diabetes mellitus. Different mechanisms have been presented underlying the therapeutic properties of diosgenin. Diosgenin with antioxidant activity and ability to inhibit pro-inflammatory and apoptotic mediators as well as modulating gut microbiota is able to protect the liver. This literature overview summarizes the previously published studies regarding the hepatoprotective function of diosgenin against liver injury in different conditions with an emphasis on possible underlying mechanisms. |
format | Online Article Text |
id | pubmed-10520708 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-105207082023-09-27 Literature review on hepatoprotective effects of diosgenin: possible mechanisms of action Mohseni-Moghaddam, Parvaneh Khanmohammadi, Manijeh Roghani, Mehrdad Front Pharmacol Pharmacology Liver diseases are among the major causes of death worldwide. Alcohol consumption, obesity, diabetes mellitus, viral infection, and drug-induced liver injury are common risk factors for the development of liver diseases. Diosgenin is a herbal steroidal sapogenin with hepatoprotective properties. This phytosteroid modulates lipid profile and prevents liver injury and fibrosis, metabolic associated fatty liver disease (MAFLD), steatohepatitis, and diabetes mellitus. Different mechanisms have been presented underlying the therapeutic properties of diosgenin. Diosgenin with antioxidant activity and ability to inhibit pro-inflammatory and apoptotic mediators as well as modulating gut microbiota is able to protect the liver. This literature overview summarizes the previously published studies regarding the hepatoprotective function of diosgenin against liver injury in different conditions with an emphasis on possible underlying mechanisms. Frontiers Media S.A. 2023-09-12 /pmc/articles/PMC10520708/ /pubmed/37767400 http://dx.doi.org/10.3389/fphar.2023.1226548 Text en Copyright © 2023 Mohseni-Moghaddam, Khanmohammadi and Roghani. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Pharmacology Mohseni-Moghaddam, Parvaneh Khanmohammadi, Manijeh Roghani, Mehrdad Literature review on hepatoprotective effects of diosgenin: possible mechanisms of action |
title | Literature review on hepatoprotective effects of diosgenin: possible mechanisms of action |
title_full | Literature review on hepatoprotective effects of diosgenin: possible mechanisms of action |
title_fullStr | Literature review on hepatoprotective effects of diosgenin: possible mechanisms of action |
title_full_unstemmed | Literature review on hepatoprotective effects of diosgenin: possible mechanisms of action |
title_short | Literature review on hepatoprotective effects of diosgenin: possible mechanisms of action |
title_sort | literature review on hepatoprotective effects of diosgenin: possible mechanisms of action |
topic | Pharmacology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10520708/ https://www.ncbi.nlm.nih.gov/pubmed/37767400 http://dx.doi.org/10.3389/fphar.2023.1226548 |
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