Cardiac safety assessment of a novel recombinant bispecific antibody targeting the ether-à-go-go related gene 1 (hERG1)-β1 integrin macromolecular complex

Introduction: In the last decades, mounting evidence has pointed out the human ether-á-go-go–related gene (hERG1) potassium channel as a novel biomarker in human cancers. However, hERG1 sustains the cardiac repolarizing current IKr and its blockade can induce a prolonged QT interval at the ECG, whic...

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Detalles Bibliográficos
Autores principales: Santini, Lorenzo, Duranti, Claudia, Palandri, Chiara, Giammarino, Lucrezia, Musumeci, Monica, Carlucci, Lucia, Capitani, Chiara, Colasurdo, Rossella, Recchia, Fabio, Cerbai, Elisabetta, Coppini, Raffaele, Arcangeli, Annarosa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10520717/
https://www.ncbi.nlm.nih.gov/pubmed/37767396
http://dx.doi.org/10.3389/fphar.2023.1237431

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10520717/
https://www.ncbi.nlm.nih.gov/pubmed/37767396
http://dx.doi.org/10.3389/fphar.2023.1237431

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