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GABA(A) receptor availability relates to emotion-induced BOLD responses in the medial prefrontal cortex: simultaneous fMRI/PET with [(11)C]flumazenil

INTRODUCTION: The fMRI BOLD response to emotional stimuli highlighting the role of the medial prefrontal cortex (MPFC) has been thoroughly investigated. Recently, the relationship between emotion processing and GABA levels has been studied using MPFC proton magnetic resonance spectroscopy (1H-MRS)....

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Autores principales: Heinzel, Alexander, Mauler, Jörg, Herzog, Hans, Boers, Frank, Mottaghy, Felix M., Langen, Karl-Josef, Scheins, Jürgen, Lerche, Christoph, Neumaier, Bernd, Northoff, Georg, Shah, N. Jon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10520870/
https://www.ncbi.nlm.nih.gov/pubmed/37766785
http://dx.doi.org/10.3389/fnins.2023.1027697
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author Heinzel, Alexander
Mauler, Jörg
Herzog, Hans
Boers, Frank
Mottaghy, Felix M.
Langen, Karl-Josef
Scheins, Jürgen
Lerche, Christoph
Neumaier, Bernd
Northoff, Georg
Shah, N. Jon
author_facet Heinzel, Alexander
Mauler, Jörg
Herzog, Hans
Boers, Frank
Mottaghy, Felix M.
Langen, Karl-Josef
Scheins, Jürgen
Lerche, Christoph
Neumaier, Bernd
Northoff, Georg
Shah, N. Jon
author_sort Heinzel, Alexander
collection PubMed
description INTRODUCTION: The fMRI BOLD response to emotional stimuli highlighting the role of the medial prefrontal cortex (MPFC) has been thoroughly investigated. Recently, the relationship between emotion processing and GABA levels has been studied using MPFC proton magnetic resonance spectroscopy (1H-MRS). However, the role of GABAA receptors in the MPFC during emotion processing remains unexplored. METHODS: Using [11C]flumazenil PET, we investigated the relationship between the binding potential of GABAA receptors and emotion processing as measured using simultaneous fMRI BOLD. We hypothesized a correlation between the percent signal change in the BOLD signal and the binding potential of GABAA receptors in the MPFC. In a combined simultaneous fMRI and [11C]flumazenil-PET study, we analyzed the data from 15 healthy subjects using visual emotional stimuli. Our task comprised two types of emotional processing: passive viewing and appraisal. Following the administration of a bolus plus infusion protocol, PET and fMRI data were simultaneously acquired in a hybrid 3 T MR-BrainPET. RESULTS: We found a differential correlation of BOLD percent signal change with [11C]flumazenil binding potential in the MPFC. Specifically, [11C]flumazenil binding potential in the ventromedial prefrontal cortex (vMPFC) correlated with passive viewing of emotionally valenced pictures. In contrast, the [11C]flumazenil binding potential and the BOLD signal induced by picture appraisal did show a correlation in the paracingulate gyrus. CONCLUSION: Our data deliver first evidence for a relationship between MPFC GABAA receptors and emotion processing in the same region. Moreover, we observed that GABAA receptors appear to play different roles in emotion processing in the vMPFC (passive viewing) and paracingulate gyrus (appraisal).
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spelling pubmed-105208702023-09-27 GABA(A) receptor availability relates to emotion-induced BOLD responses in the medial prefrontal cortex: simultaneous fMRI/PET with [(11)C]flumazenil Heinzel, Alexander Mauler, Jörg Herzog, Hans Boers, Frank Mottaghy, Felix M. Langen, Karl-Josef Scheins, Jürgen Lerche, Christoph Neumaier, Bernd Northoff, Georg Shah, N. Jon Front Neurosci Neuroscience INTRODUCTION: The fMRI BOLD response to emotional stimuli highlighting the role of the medial prefrontal cortex (MPFC) has been thoroughly investigated. Recently, the relationship between emotion processing and GABA levels has been studied using MPFC proton magnetic resonance spectroscopy (1H-MRS). However, the role of GABAA receptors in the MPFC during emotion processing remains unexplored. METHODS: Using [11C]flumazenil PET, we investigated the relationship between the binding potential of GABAA receptors and emotion processing as measured using simultaneous fMRI BOLD. We hypothesized a correlation between the percent signal change in the BOLD signal and the binding potential of GABAA receptors in the MPFC. In a combined simultaneous fMRI and [11C]flumazenil-PET study, we analyzed the data from 15 healthy subjects using visual emotional stimuli. Our task comprised two types of emotional processing: passive viewing and appraisal. Following the administration of a bolus plus infusion protocol, PET and fMRI data were simultaneously acquired in a hybrid 3 T MR-BrainPET. RESULTS: We found a differential correlation of BOLD percent signal change with [11C]flumazenil binding potential in the MPFC. Specifically, [11C]flumazenil binding potential in the ventromedial prefrontal cortex (vMPFC) correlated with passive viewing of emotionally valenced pictures. In contrast, the [11C]flumazenil binding potential and the BOLD signal induced by picture appraisal did show a correlation in the paracingulate gyrus. CONCLUSION: Our data deliver first evidence for a relationship between MPFC GABAA receptors and emotion processing in the same region. Moreover, we observed that GABAA receptors appear to play different roles in emotion processing in the vMPFC (passive viewing) and paracingulate gyrus (appraisal). Frontiers Media S.A. 2023-09-12 /pmc/articles/PMC10520870/ /pubmed/37766785 http://dx.doi.org/10.3389/fnins.2023.1027697 Text en Copyright © 2023 Heinzel, Mauler, Herzog, Boers, Mottaghy, Langen, Scheins, Lerche, Neumaier, Northoff and Shah. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Heinzel, Alexander
Mauler, Jörg
Herzog, Hans
Boers, Frank
Mottaghy, Felix M.
Langen, Karl-Josef
Scheins, Jürgen
Lerche, Christoph
Neumaier, Bernd
Northoff, Georg
Shah, N. Jon
GABA(A) receptor availability relates to emotion-induced BOLD responses in the medial prefrontal cortex: simultaneous fMRI/PET with [(11)C]flumazenil
title GABA(A) receptor availability relates to emotion-induced BOLD responses in the medial prefrontal cortex: simultaneous fMRI/PET with [(11)C]flumazenil
title_full GABA(A) receptor availability relates to emotion-induced BOLD responses in the medial prefrontal cortex: simultaneous fMRI/PET with [(11)C]flumazenil
title_fullStr GABA(A) receptor availability relates to emotion-induced BOLD responses in the medial prefrontal cortex: simultaneous fMRI/PET with [(11)C]flumazenil
title_full_unstemmed GABA(A) receptor availability relates to emotion-induced BOLD responses in the medial prefrontal cortex: simultaneous fMRI/PET with [(11)C]flumazenil
title_short GABA(A) receptor availability relates to emotion-induced BOLD responses in the medial prefrontal cortex: simultaneous fMRI/PET with [(11)C]flumazenil
title_sort gaba(a) receptor availability relates to emotion-induced bold responses in the medial prefrontal cortex: simultaneous fmri/pet with [(11)c]flumazenil
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10520870/
https://www.ncbi.nlm.nih.gov/pubmed/37766785
http://dx.doi.org/10.3389/fnins.2023.1027697
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