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The autoactivation of human single-chain urokinase-type plasminogen activator (uPA)

Most serine proteases are synthesized as inactive zymogens that are activated by cleavage by another protease in a tightly regulated mechanism. The urokinase-type plasminogen activator (uPA) and plasmin cleave and activate each other, constituting a positive feedback loop. How this mutual activation...

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Detalles Bibliográficos
Autores principales:	Torres-Paris, Constanza, Chen, Yueyi, Xiao, Lufan, Song, Harriet J., Chen, Pingyu, Komives, Elizabeth A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10520878/ https://www.ncbi.nlm.nih.gov/pubmed/37607618 http://dx.doi.org/10.1016/j.jbc.2023.105179

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