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The biased M3 mAChR ligand PD 102807 mediates qualitatively distinct signaling to regulate airway smooth muscle phenotype

Airway smooth muscle (ASM) cells attain a hypercontractile phenotype during obstructive airway diseases. We recently identified a biased M3 muscarinic acetylcholine receptor (mAChR) ligand, PD 102807, that induces GRK-/arrestin-dependent AMP-activated protein kinase (AMPK) activation to inhibit tran...

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Detalles Bibliográficos
Autores principales:	Tompkins, Eric, Mimic, Bogdana, Penn, Raymond B., Pera, Tonio
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10520882/ https://www.ncbi.nlm.nih.gov/pubmed/37660916 http://dx.doi.org/10.1016/j.jbc.2023.105209

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