Sialylation of EGFR by ST6GAL1 induces receptor activation and modulates trafficking dynamics

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Aberrant glycosylation is a hallmark of a cancer cell. One prevalent alteration is an enrichment in α2,6-linked sialylation of N-glycosylated proteins, a modification directed by the ST6GAL1 sialyltransferase. ST6GAL1 is upregulated in many malignancies including ovarian cancer. Prior studies have s...

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Detalles Bibliográficos
Autores principales: Ankenbauer, Katherine E., Rao, Tejeshwar C., Mattheyses, Alexa L., Bellis, Susan L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10520885/
https://www.ncbi.nlm.nih.gov/pubmed/37660914
http://dx.doi.org/10.1016/j.jbc.2023.105217

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