G protein–receptor kinases 5/6 are the key regulators of G protein–coupled receptor 35–arrestin interactions

Human G protein–coupled receptor 35 is regulated by agonist-mediated phosphorylation of a set of five phospho-acceptor amino acids within its C-terminal tail. Alteration of both Ser(300) and Ser(303) to alanine in the GPR35a isoform greatly reduces the ability of receptor agonists to promote interac...

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Detalles Bibliográficos
Autores principales: Ganguly, Amlan, Quon, Tezz, Jenkins, Laura, Joseph, Babu, Al-awar, Rima, Chevigne, Andy, Tobin, Andrew B., Uehling, David E., Hoffmann, Carsten, Drube, Julia, Milligan, Graeme
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10520886/
https://www.ncbi.nlm.nih.gov/pubmed/37660910
http://dx.doi.org/10.1016/j.jbc.2023.105218

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