Baricitinib treatment for refractory skin changes in POEMS syndrome: a case report

Polyneuropathy, organomegaly, endocrinopathy, monoclonal plasma cell disorder, and skin changes (POEMS) syndrome is a multisystem disorder that has limited treatment options. Here, we described a case of a 55-year-old female subject who was treated for multiple drugs, but the skin symptoms continued...

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Detalles Bibliográficos
Autores principales: Xie, Jingjing, Li, Zhiling, Jiang, Yubao, Tang, Dabin, Qiu, Xia, Jia, Ertao, Zhang, Jianyong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10520952/
https://www.ncbi.nlm.nih.gov/pubmed/37767406
http://dx.doi.org/10.3389/fphar.2023.1191158
Descripción
Sumario:Polyneuropathy, organomegaly, endocrinopathy, monoclonal plasma cell disorder, and skin changes (POEMS) syndrome is a multisystem disorder that has limited treatment options. Here, we described a case of a 55-year-old female subject who was treated for multiple drugs, but the skin symptoms continued to progress; the patient responded well to baricitinib. This suggests that JAK/STAT signaling pathways play an essential role in the pathological process of POEMS syndrome.

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