Baricitinib treatment for refractory skin changes in POEMS syndrome: a case report

Polyneuropathy, organomegaly, endocrinopathy, monoclonal plasma cell disorder, and skin changes (POEMS) syndrome is a multisystem disorder that has limited treatment options. Here, we described a case of a 55-year-old female subject who was treated for multiple drugs, but the skin symptoms continued...

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Detalles Bibliográficos
Autores principales: Xie, Jingjing, Li, Zhiling, Jiang, Yubao, Tang, Dabin, Qiu, Xia, Jia, Ertao, Zhang, Jianyong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10520952/
https://www.ncbi.nlm.nih.gov/pubmed/37767406
http://dx.doi.org/10.3389/fphar.2023.1191158
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author Xie, Jingjing
Li, Zhiling
Jiang, Yubao
Tang, Dabin
Qiu, Xia
Jia, Ertao
Zhang, Jianyong
author_facet Xie, Jingjing
Li, Zhiling
Jiang, Yubao
Tang, Dabin
Qiu, Xia
Jia, Ertao
Zhang, Jianyong
author_sort Xie, Jingjing
collection PubMed
description Polyneuropathy, organomegaly, endocrinopathy, monoclonal plasma cell disorder, and skin changes (POEMS) syndrome is a multisystem disorder that has limited treatment options. Here, we described a case of a 55-year-old female subject who was treated for multiple drugs, but the skin symptoms continued to progress; the patient responded well to baricitinib. This suggests that JAK/STAT signaling pathways play an essential role in the pathological process of POEMS syndrome.
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spelling pubmed-105209522023-09-27 Baricitinib treatment for refractory skin changes in POEMS syndrome: a case report Xie, Jingjing Li, Zhiling Jiang, Yubao Tang, Dabin Qiu, Xia Jia, Ertao Zhang, Jianyong Front Pharmacol Pharmacology Polyneuropathy, organomegaly, endocrinopathy, monoclonal plasma cell disorder, and skin changes (POEMS) syndrome is a multisystem disorder that has limited treatment options. Here, we described a case of a 55-year-old female subject who was treated for multiple drugs, but the skin symptoms continued to progress; the patient responded well to baricitinib. This suggests that JAK/STAT signaling pathways play an essential role in the pathological process of POEMS syndrome. Frontiers Media S.A. 2023-09-12 /pmc/articles/PMC10520952/ /pubmed/37767406 http://dx.doi.org/10.3389/fphar.2023.1191158 Text en Copyright © 2023 Xie, Li, Jiang, Tang, Qiu, Jia and Zhang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pharmacology
Xie, Jingjing
Li, Zhiling
Jiang, Yubao
Tang, Dabin
Qiu, Xia
Jia, Ertao
Zhang, Jianyong
Baricitinib treatment for refractory skin changes in POEMS syndrome: a case report
title Baricitinib treatment for refractory skin changes in POEMS syndrome: a case report
title_full Baricitinib treatment for refractory skin changes in POEMS syndrome: a case report
title_fullStr Baricitinib treatment for refractory skin changes in POEMS syndrome: a case report
title_full_unstemmed Baricitinib treatment for refractory skin changes in POEMS syndrome: a case report
title_short Baricitinib treatment for refractory skin changes in POEMS syndrome: a case report
title_sort baricitinib treatment for refractory skin changes in poems syndrome: a case report
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10520952/
https://www.ncbi.nlm.nih.gov/pubmed/37767406
http://dx.doi.org/10.3389/fphar.2023.1191158
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