Pharmacological rescue of mitochondrial and neuronal defects in SPG7 hereditary spastic paraplegia patient neurons using high throughput assays

SPG7 is the most common form of autosomal recessive hereditary spastic paraplegia (HSP). There is a lack of HSP-SPG7 human neuronal models to understand the disease mechanism and identify new drug treatments. We generated a human neuronal model of HSP-SPG7 using induced pluripotent stem (iPS) cell t...

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Detalles Bibliográficos
Autores principales: Wali, Gautam, Li, Yan, Liyanage, Erandhi, Kumar, Kishore R., Day, Margot L., Sue, Carolyn M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10520970/
https://www.ncbi.nlm.nih.gov/pubmed/37766787
http://dx.doi.org/10.3389/fnins.2023.1231584

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10520970/
https://www.ncbi.nlm.nih.gov/pubmed/37766787
http://dx.doi.org/10.3389/fnins.2023.1231584

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