Reversing T Cell Exhaustion by Converting Membrane PD-1 to Its Soluble form in Jurkat Cells; Applying The CRISPR/Cas9 Exon Skipping Strategy

OBJECTIVE: T-cells express two functional forms of the programmed cell death protein 1 (PD-1): membrane (mPD-1) and soluble (sPD-1). The binding of mPD-1 and its ligand (PD-L1) on tumor cells could lead activated lymphocytes toward exhaustion. Selective deletion of the transmembrane domain via alter...

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Detalles Bibliográficos
Autores principales: Yousefi-Najafabadi, Zeinab, Mehmandoostli, Zohreh, Asgari, Yazdan, Kaboli, Saeed, Falak, Reza, Kardar, Gholam Ali
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royan Institute 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10520982/
https://www.ncbi.nlm.nih.gov/pubmed/37718766
http://dx.doi.org/10.22074/CELLJ.2023.1999548.1269

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