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Generation of Mouse Model of Hemophilia A by Introducing Novel Mutations, Using CRISPR/Nickase Gene Targeting System
Developing mouse models of hemophilia A has been shown to facilitate in vivo studies to explore the probable mechanism(s) underlying the disease and to examine the efficiency of the relevant potential therapeutics. This study aimed to knockout (KO) the coagulation factor viii (fviii) gene in NMRI mi...
Autores principales: | Shamsara, Mehdi, Jamshidizad, Abbas, Rahim-Tayfeh, Aidin, Davari, Maliheh, Rajabi Zangi, Ali, Masoumi, Fatemeh, Zomorodipour, Alireza |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Royan Institute
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10520988/ https://www.ncbi.nlm.nih.gov/pubmed/37718768 http://dx.doi.org/10.22074/CELLJ.2023.1999800.1278 |
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