Cu-Catalyzed Enantioselective Protoboration of 2,3-Disubstituted 1,3-Dienes

[Image: see text] A Cu-catalyzed regio- and enantioselective protoboration of 2,3-disubstituted 1,3-dienes is described. The protocol operates under mild conditions and is applicable to symmetrically and unsymmetrically substituted dienes, providing access to homoallylic boronates in consistently hi...

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Detalles Bibliográficos
Autores principales: Liu, Sensheng, Liu, Yangbin, Flaget, Arthur, Zhang, Cheng, Mazet, Clément
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10521025/
https://www.ncbi.nlm.nih.gov/pubmed/37695719
http://dx.doi.org/10.1021/acs.orglett.3c02627
Descripción
Sumario:[Image: see text] A Cu-catalyzed regio- and enantioselective protoboration of 2,3-disubstituted 1,3-dienes is described. The protocol operates under mild conditions and is applicable to symmetrically and unsymmetrically substituted dienes, providing access to homoallylic boronates in consistently high yield, regioselectivity, and enantiomeric ratio. Preliminary investigations point to a complex mechanism.

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