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Trends and Disparities in Stage-Specific Incidence of Hepatocellular Carcinoma among US Adults, 2004–2019

INTRODUCTION: The aim of this study was to determine the stage-specific incidence trend of hepatocellular carcinoma (HCC) among US adults. METHODS: The age-adjusted incidence rate was extracted from Surveillance, Epidemiology, and End Results database for localized, regional, and distant HCC. Trend...

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Autores principales: Shi, Haoting, Huang, Jingxuan, Zhao, Shi, Jin, Yiwen, Cai, Rong, Ran, Jinjun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: S. Karger AG 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10521315/
https://www.ncbi.nlm.nih.gov/pubmed/37767065
http://dx.doi.org/10.1159/000528374
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author Shi, Haoting
Huang, Jingxuan
Zhao, Shi
Jin, Yiwen
Cai, Rong
Ran, Jinjun
author_facet Shi, Haoting
Huang, Jingxuan
Zhao, Shi
Jin, Yiwen
Cai, Rong
Ran, Jinjun
author_sort Shi, Haoting
collection PubMed
description INTRODUCTION: The aim of this study was to determine the stage-specific incidence trend of hepatocellular carcinoma (HCC) among US adults. METHODS: The age-adjusted incidence rate was extracted from Surveillance, Epidemiology, and End Results database for localized, regional, and distant HCC. Trend analyses were conducted in the overall population and stratified by demographic and sociodemographic variables. The annual percentage change (APC) in 2014–2019 was estimated to determine the stage-specific incidence trend. RESULTS: Although the incidence of localized HCC significantly declined, the incidence for regional and distant HCC plateaued in 2014–2019 (APCs, 4.4% [95% CI, −0.2% to 9.3%] and −0.7% [95% CI, −1.8% to 0.5%], respectively) with age and race/ethnicity disparities. More pronounced increases for regional and distant HCC were observed among the elderly (APCs, 8.4% [95% CI, 4.8–12.2%] and 2.2% [95% CI, 1.7–2.7%] for regional and distant HCC, respectively), non-Hispanic white individuals (APCs, 4.0% [95% CI, 2.9–5.1%] and 1.5% [95% CI, 0.7–2.4%] for regional and distant HCC, respectively). CONCLUSIONS: Disparities in incidence trends may reflect the inequalities in access to primary health care. More efforts are still in great demand for the vulnerable population.
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spelling pubmed-105213152023-09-27 Trends and Disparities in Stage-Specific Incidence of Hepatocellular Carcinoma among US Adults, 2004–2019 Shi, Haoting Huang, Jingxuan Zhao, Shi Jin, Yiwen Cai, Rong Ran, Jinjun Liver Cancer Brief Report INTRODUCTION: The aim of this study was to determine the stage-specific incidence trend of hepatocellular carcinoma (HCC) among US adults. METHODS: The age-adjusted incidence rate was extracted from Surveillance, Epidemiology, and End Results database for localized, regional, and distant HCC. Trend analyses were conducted in the overall population and stratified by demographic and sociodemographic variables. The annual percentage change (APC) in 2014–2019 was estimated to determine the stage-specific incidence trend. RESULTS: Although the incidence of localized HCC significantly declined, the incidence for regional and distant HCC plateaued in 2014–2019 (APCs, 4.4% [95% CI, −0.2% to 9.3%] and −0.7% [95% CI, −1.8% to 0.5%], respectively) with age and race/ethnicity disparities. More pronounced increases for regional and distant HCC were observed among the elderly (APCs, 8.4% [95% CI, 4.8–12.2%] and 2.2% [95% CI, 1.7–2.7%] for regional and distant HCC, respectively), non-Hispanic white individuals (APCs, 4.0% [95% CI, 2.9–5.1%] and 1.5% [95% CI, 0.7–2.4%] for regional and distant HCC, respectively). CONCLUSIONS: Disparities in incidence trends may reflect the inequalities in access to primary health care. More efforts are still in great demand for the vulnerable population. S. Karger AG 2022-12-05 /pmc/articles/PMC10521315/ /pubmed/37767065 http://dx.doi.org/10.1159/000528374 Text en Copyright © 2022 by The Author(s). Published by S. Karger AG, Basel https://creativecommons.org/licenses/by-nc/4.0/This article is licensed under the Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC). Usage and distribution for commercial purposes requires written permission.
spellingShingle Brief Report
Shi, Haoting
Huang, Jingxuan
Zhao, Shi
Jin, Yiwen
Cai, Rong
Ran, Jinjun
Trends and Disparities in Stage-Specific Incidence of Hepatocellular Carcinoma among US Adults, 2004–2019
title Trends and Disparities in Stage-Specific Incidence of Hepatocellular Carcinoma among US Adults, 2004–2019
title_full Trends and Disparities in Stage-Specific Incidence of Hepatocellular Carcinoma among US Adults, 2004–2019
title_fullStr Trends and Disparities in Stage-Specific Incidence of Hepatocellular Carcinoma among US Adults, 2004–2019
title_full_unstemmed Trends and Disparities in Stage-Specific Incidence of Hepatocellular Carcinoma among US Adults, 2004–2019
title_short Trends and Disparities in Stage-Specific Incidence of Hepatocellular Carcinoma among US Adults, 2004–2019
title_sort trends and disparities in stage-specific incidence of hepatocellular carcinoma among us adults, 2004–2019
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10521315/
https://www.ncbi.nlm.nih.gov/pubmed/37767065
http://dx.doi.org/10.1159/000528374
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