BAX activation in mouse retinal ganglion cells occurs in two temporally and mechanistically distinct steps

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BACKGROUND: Pro-apoptotic BAX is a central mediator of retinal ganglion cell (RGC) death after optic nerve damage. BAX activation occurs in two stages including translocation of latent BAX to the mitochondrial outer membrane (MOM) and then permeabilization of the MOM to facilitate the release of apo...

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Detalles Bibliográficos
Autores principales: Maes, Margaret E., Donahue, Ryan J., Schlamp, Cassandra L., Marola, Olivia J., Libby, Richard T., Nickells, Robert W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10521527/
https://www.ncbi.nlm.nih.gov/pubmed/37752598
http://dx.doi.org/10.1186/s13024-023-00659-8
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