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Autophagy, a critical element in the aging male reproductive disorders and prostate cancer: a therapeutic point of view

Autophagy is a highly conserved, lysosome-dependent biological mechanism involved in the degradation and recycling of cellular components. There is growing evidence that autophagy is related to male reproductive biology, particularly spermatogenic and endocrinologic processes closely associated with...

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Autores principales: Raee, Pourya, Tan, Shing Cheng, Najafi, Sajad, Zandsalimi, Farshid, Low, Teck Yew, Aghamiri, Shahin, Fazeli, Elham, Aghapour, Mahyar, Mofarahe, Zahra Shams, Heidari, Mohammad Hossein, Fathabadi, Fatemeh Fadaei, Abdi, Farid, Asouri, Mohsen, Ahmadi, Ali Asghar, Ghanbarian, Hossein
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10521554/
https://www.ncbi.nlm.nih.gov/pubmed/37749573
http://dx.doi.org/10.1186/s12958-023-01134-1
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author Raee, Pourya
Tan, Shing Cheng
Najafi, Sajad
Zandsalimi, Farshid
Low, Teck Yew
Aghamiri, Shahin
Fazeli, Elham
Aghapour, Mahyar
Mofarahe, Zahra Shams
Heidari, Mohammad Hossein
Fathabadi, Fatemeh Fadaei
Abdi, Farid
Asouri, Mohsen
Ahmadi, Ali Asghar
Ghanbarian, Hossein
author_facet Raee, Pourya
Tan, Shing Cheng
Najafi, Sajad
Zandsalimi, Farshid
Low, Teck Yew
Aghamiri, Shahin
Fazeli, Elham
Aghapour, Mahyar
Mofarahe, Zahra Shams
Heidari, Mohammad Hossein
Fathabadi, Fatemeh Fadaei
Abdi, Farid
Asouri, Mohsen
Ahmadi, Ali Asghar
Ghanbarian, Hossein
author_sort Raee, Pourya
collection PubMed
description Autophagy is a highly conserved, lysosome-dependent biological mechanism involved in the degradation and recycling of cellular components. There is growing evidence that autophagy is related to male reproductive biology, particularly spermatogenic and endocrinologic processes closely associated with male sexual and reproductive health. In recent decades, problems such as decreasing sperm count, erectile dysfunction, and infertility have worsened. In addition, reproductive health is closely related to overall health and comorbidity in aging men. In this review, we will outline the role of autophagy as a new player in aging male reproductive dysfunction and prostate cancer. We first provide an overview of the mechanisms of autophagy and its role in regulating male reproductive cells. We then focus on the link between autophagy and aging-related diseases. This is followed by a discussion of therapeutic strategies targeting autophagy before we end with limitations of current studies and suggestions for future developments in the field.
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spelling pubmed-105215542023-09-27 Autophagy, a critical element in the aging male reproductive disorders and prostate cancer: a therapeutic point of view Raee, Pourya Tan, Shing Cheng Najafi, Sajad Zandsalimi, Farshid Low, Teck Yew Aghamiri, Shahin Fazeli, Elham Aghapour, Mahyar Mofarahe, Zahra Shams Heidari, Mohammad Hossein Fathabadi, Fatemeh Fadaei Abdi, Farid Asouri, Mohsen Ahmadi, Ali Asghar Ghanbarian, Hossein Reprod Biol Endocrinol Review Autophagy is a highly conserved, lysosome-dependent biological mechanism involved in the degradation and recycling of cellular components. There is growing evidence that autophagy is related to male reproductive biology, particularly spermatogenic and endocrinologic processes closely associated with male sexual and reproductive health. In recent decades, problems such as decreasing sperm count, erectile dysfunction, and infertility have worsened. In addition, reproductive health is closely related to overall health and comorbidity in aging men. In this review, we will outline the role of autophagy as a new player in aging male reproductive dysfunction and prostate cancer. We first provide an overview of the mechanisms of autophagy and its role in regulating male reproductive cells. We then focus on the link between autophagy and aging-related diseases. This is followed by a discussion of therapeutic strategies targeting autophagy before we end with limitations of current studies and suggestions for future developments in the field. BioMed Central 2023-09-26 /pmc/articles/PMC10521554/ /pubmed/37749573 http://dx.doi.org/10.1186/s12958-023-01134-1 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Raee, Pourya
Tan, Shing Cheng
Najafi, Sajad
Zandsalimi, Farshid
Low, Teck Yew
Aghamiri, Shahin
Fazeli, Elham
Aghapour, Mahyar
Mofarahe, Zahra Shams
Heidari, Mohammad Hossein
Fathabadi, Fatemeh Fadaei
Abdi, Farid
Asouri, Mohsen
Ahmadi, Ali Asghar
Ghanbarian, Hossein
Autophagy, a critical element in the aging male reproductive disorders and prostate cancer: a therapeutic point of view
title Autophagy, a critical element in the aging male reproductive disorders and prostate cancer: a therapeutic point of view
title_full Autophagy, a critical element in the aging male reproductive disorders and prostate cancer: a therapeutic point of view
title_fullStr Autophagy, a critical element in the aging male reproductive disorders and prostate cancer: a therapeutic point of view
title_full_unstemmed Autophagy, a critical element in the aging male reproductive disorders and prostate cancer: a therapeutic point of view
title_short Autophagy, a critical element in the aging male reproductive disorders and prostate cancer: a therapeutic point of view
title_sort autophagy, a critical element in the aging male reproductive disorders and prostate cancer: a therapeutic point of view
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10521554/
https://www.ncbi.nlm.nih.gov/pubmed/37749573
http://dx.doi.org/10.1186/s12958-023-01134-1
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