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Carbapenem-Resistant Klebsiella pneumoniae in Large Public Acute-Care Healthcare System, New York, New York, USA, 2016–2022
Controlling the spread of carbapenem-resistant Enterobacterales is a global priority. Using National Healthcare Safety Network data, we characterized the changing epidemiology of carbapenem-resistant Klebsiella pneumoniae (CRKP) in a large public health system in New York, New York, USA. During 2016...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Centers for Disease Control and Prevention
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10521592/ https://www.ncbi.nlm.nih.gov/pubmed/37735742 http://dx.doi.org/10.3201/eid2910.230153 |
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author | Lee, Jennifer Sunny, Subin Nazarian, Elizabeth Fornek, Mary Abdallah, Marie Episcopia, Briana Rowlinson, Marie-Claire Quale, John |
author_facet | Lee, Jennifer Sunny, Subin Nazarian, Elizabeth Fornek, Mary Abdallah, Marie Episcopia, Briana Rowlinson, Marie-Claire Quale, John |
author_sort | Lee, Jennifer |
collection | PubMed |
description | Controlling the spread of carbapenem-resistant Enterobacterales is a global priority. Using National Healthcare Safety Network data, we characterized the changing epidemiology of carbapenem-resistant Klebsiella pneumoniae (CRKP) in a large public health system in New York, New York, USA. During 2016–2020, CRKP cases declined; however, during 2021–June 2022, a notable increase occurred. Of 509 cases, 262 (51%) were considered community-onset, including 149 in patients who were living at home. Of 182 isolates with proven or presumptive (ceftazidime/avibactam susceptible) enzymes, 143 were serine carbapenemases; most confirmed cases were K. pneumoniae carbapenemase. The remaining 39 cases were proven or presumptive metallo-β-lactamases; all confirmed cases were New Delhi metallo-β-lactamases. After 2020, a marked increase occurred in the percentage of isolates possessing metallo-β-lactamases. Most patients with metallo-β-lactamases originated from long-term care facilities. An aggressive and universal program involving surveillance and isolation will be needed to control the spread of CRKP in the city of New York. |
format | Online Article Text |
id | pubmed-10521592 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Centers for Disease Control and Prevention |
record_format | MEDLINE/PubMed |
spelling | pubmed-105215922023-10-01 Carbapenem-Resistant Klebsiella pneumoniae in Large Public Acute-Care Healthcare System, New York, New York, USA, 2016–2022 Lee, Jennifer Sunny, Subin Nazarian, Elizabeth Fornek, Mary Abdallah, Marie Episcopia, Briana Rowlinson, Marie-Claire Quale, John Emerg Infect Dis Synopsis Controlling the spread of carbapenem-resistant Enterobacterales is a global priority. Using National Healthcare Safety Network data, we characterized the changing epidemiology of carbapenem-resistant Klebsiella pneumoniae (CRKP) in a large public health system in New York, New York, USA. During 2016–2020, CRKP cases declined; however, during 2021–June 2022, a notable increase occurred. Of 509 cases, 262 (51%) were considered community-onset, including 149 in patients who were living at home. Of 182 isolates with proven or presumptive (ceftazidime/avibactam susceptible) enzymes, 143 were serine carbapenemases; most confirmed cases were K. pneumoniae carbapenemase. The remaining 39 cases were proven or presumptive metallo-β-lactamases; all confirmed cases were New Delhi metallo-β-lactamases. After 2020, a marked increase occurred in the percentage of isolates possessing metallo-β-lactamases. Most patients with metallo-β-lactamases originated from long-term care facilities. An aggressive and universal program involving surveillance and isolation will be needed to control the spread of CRKP in the city of New York. Centers for Disease Control and Prevention 2023-10 /pmc/articles/PMC10521592/ /pubmed/37735742 http://dx.doi.org/10.3201/eid2910.230153 Text en https://creativecommons.org/licenses/by/4.0/Emerging Infectious Diseases is a publication of the U.S. Government. This publication is in the public domain and is therefore without copyright. All text from this work may be reprinted freely. Use of these materials should be properly cited. |
spellingShingle | Synopsis Lee, Jennifer Sunny, Subin Nazarian, Elizabeth Fornek, Mary Abdallah, Marie Episcopia, Briana Rowlinson, Marie-Claire Quale, John Carbapenem-Resistant Klebsiella pneumoniae in Large Public Acute-Care Healthcare System, New York, New York, USA, 2016–2022 |
title | Carbapenem-Resistant Klebsiella pneumoniae in Large Public Acute-Care Healthcare System, New York, New York, USA, 2016–2022 |
title_full | Carbapenem-Resistant Klebsiella pneumoniae in Large Public Acute-Care Healthcare System, New York, New York, USA, 2016–2022 |
title_fullStr | Carbapenem-Resistant Klebsiella pneumoniae in Large Public Acute-Care Healthcare System, New York, New York, USA, 2016–2022 |
title_full_unstemmed | Carbapenem-Resistant Klebsiella pneumoniae in Large Public Acute-Care Healthcare System, New York, New York, USA, 2016–2022 |
title_short | Carbapenem-Resistant Klebsiella pneumoniae in Large Public Acute-Care Healthcare System, New York, New York, USA, 2016–2022 |
title_sort | carbapenem-resistant klebsiella pneumoniae in large public acute-care healthcare system, new york, new york, usa, 2016–2022 |
topic | Synopsis |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10521592/ https://www.ncbi.nlm.nih.gov/pubmed/37735742 http://dx.doi.org/10.3201/eid2910.230153 |
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