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Carbapenem-Resistant Klebsiella pneumoniae in Large Public Acute-Care Healthcare System, New York, New York, USA, 2016–2022

Controlling the spread of carbapenem-resistant Enterobacterales is a global priority. Using National Healthcare Safety Network data, we characterized the changing epidemiology of carbapenem-resistant Klebsiella pneumoniae (CRKP) in a large public health system in New York, New York, USA. During 2016...

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Autores principales: Lee, Jennifer, Sunny, Subin, Nazarian, Elizabeth, Fornek, Mary, Abdallah, Marie, Episcopia, Briana, Rowlinson, Marie-Claire, Quale, John
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Centers for Disease Control and Prevention 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10521592/
https://www.ncbi.nlm.nih.gov/pubmed/37735742
http://dx.doi.org/10.3201/eid2910.230153
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author Lee, Jennifer
Sunny, Subin
Nazarian, Elizabeth
Fornek, Mary
Abdallah, Marie
Episcopia, Briana
Rowlinson, Marie-Claire
Quale, John
author_facet Lee, Jennifer
Sunny, Subin
Nazarian, Elizabeth
Fornek, Mary
Abdallah, Marie
Episcopia, Briana
Rowlinson, Marie-Claire
Quale, John
author_sort Lee, Jennifer
collection PubMed
description Controlling the spread of carbapenem-resistant Enterobacterales is a global priority. Using National Healthcare Safety Network data, we characterized the changing epidemiology of carbapenem-resistant Klebsiella pneumoniae (CRKP) in a large public health system in New York, New York, USA. During 2016–2020, CRKP cases declined; however, during 2021–June 2022, a notable increase occurred. Of 509 cases, 262 (51%) were considered community-onset, including 149 in patients who were living at home. Of 182 isolates with proven or presumptive (ceftazidime/avibactam susceptible) enzymes, 143 were serine carbapenemases; most confirmed cases were K. pneumoniae carbapenemase. The remaining 39 cases were proven or presumptive metallo-β-lactamases; all confirmed cases were New Delhi metallo-β-lactamases. After 2020, a marked increase occurred in the percentage of isolates possessing metallo-β-lactamases. Most patients with metallo-β-lactamases originated from long-term care facilities. An aggressive and universal program involving surveillance and isolation will be needed to control the spread of CRKP in the city of New York.
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spelling pubmed-105215922023-10-01 Carbapenem-Resistant Klebsiella pneumoniae in Large Public Acute-Care Healthcare System, New York, New York, USA, 2016–2022 Lee, Jennifer Sunny, Subin Nazarian, Elizabeth Fornek, Mary Abdallah, Marie Episcopia, Briana Rowlinson, Marie-Claire Quale, John Emerg Infect Dis Synopsis Controlling the spread of carbapenem-resistant Enterobacterales is a global priority. Using National Healthcare Safety Network data, we characterized the changing epidemiology of carbapenem-resistant Klebsiella pneumoniae (CRKP) in a large public health system in New York, New York, USA. During 2016–2020, CRKP cases declined; however, during 2021–June 2022, a notable increase occurred. Of 509 cases, 262 (51%) were considered community-onset, including 149 in patients who were living at home. Of 182 isolates with proven or presumptive (ceftazidime/avibactam susceptible) enzymes, 143 were serine carbapenemases; most confirmed cases were K. pneumoniae carbapenemase. The remaining 39 cases were proven or presumptive metallo-β-lactamases; all confirmed cases were New Delhi metallo-β-lactamases. After 2020, a marked increase occurred in the percentage of isolates possessing metallo-β-lactamases. Most patients with metallo-β-lactamases originated from long-term care facilities. An aggressive and universal program involving surveillance and isolation will be needed to control the spread of CRKP in the city of New York. Centers for Disease Control and Prevention 2023-10 /pmc/articles/PMC10521592/ /pubmed/37735742 http://dx.doi.org/10.3201/eid2910.230153 Text en https://creativecommons.org/licenses/by/4.0/Emerging Infectious Diseases is a publication of the U.S. Government. This publication is in the public domain and is therefore without copyright. All text from this work may be reprinted freely. Use of these materials should be properly cited.
spellingShingle Synopsis
Lee, Jennifer
Sunny, Subin
Nazarian, Elizabeth
Fornek, Mary
Abdallah, Marie
Episcopia, Briana
Rowlinson, Marie-Claire
Quale, John
Carbapenem-Resistant Klebsiella pneumoniae in Large Public Acute-Care Healthcare System, New York, New York, USA, 2016–2022
title Carbapenem-Resistant Klebsiella pneumoniae in Large Public Acute-Care Healthcare System, New York, New York, USA, 2016–2022
title_full Carbapenem-Resistant Klebsiella pneumoniae in Large Public Acute-Care Healthcare System, New York, New York, USA, 2016–2022
title_fullStr Carbapenem-Resistant Klebsiella pneumoniae in Large Public Acute-Care Healthcare System, New York, New York, USA, 2016–2022
title_full_unstemmed Carbapenem-Resistant Klebsiella pneumoniae in Large Public Acute-Care Healthcare System, New York, New York, USA, 2016–2022
title_short Carbapenem-Resistant Klebsiella pneumoniae in Large Public Acute-Care Healthcare System, New York, New York, USA, 2016–2022
title_sort carbapenem-resistant klebsiella pneumoniae in large public acute-care healthcare system, new york, new york, usa, 2016–2022
topic Synopsis
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10521592/
https://www.ncbi.nlm.nih.gov/pubmed/37735742
http://dx.doi.org/10.3201/eid2910.230153
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