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Sporadic Shiga Toxin–Producing Escherichia coli–Associated Pediatric Hemolytic Uremic Syndrome, France, 2012–2021
Shiga toxin–producing Escherichia coli–associated pediatric hemolytic uremic syndrome (STEC-HUS) remains an important public health risk in France. Cases are primarily sporadic, and geographic heterogeneity has been observed in crude incidence rates. We conducted a retrospective study of 1,255 spora...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Centers for Disease Control and Prevention
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10521606/ https://www.ncbi.nlm.nih.gov/pubmed/37735746 http://dx.doi.org/10.3201/eid2910.230382 |
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author | Jones, Gabrielle Mariani-Kurkdjian, Patricia Cointe, Aurélie Bonacorsi, Stéphane Lefèvre, Sophie Weill, François-Xavier Le Strat, Yann |
author_facet | Jones, Gabrielle Mariani-Kurkdjian, Patricia Cointe, Aurélie Bonacorsi, Stéphane Lefèvre, Sophie Weill, François-Xavier Le Strat, Yann |
author_sort | Jones, Gabrielle |
collection | PubMed |
description | Shiga toxin–producing Escherichia coli–associated pediatric hemolytic uremic syndrome (STEC-HUS) remains an important public health risk in France. Cases are primarily sporadic, and geographic heterogeneity has been observed in crude incidence rates. We conducted a retrospective study of 1,255 sporadic pediatric STEC-HUS cases reported during 2012–2021 to describe spatiotemporal dynamics and geographic patterns of higher STEC-HUS risk. Annual case notifications ranged from 109 to 163. Most cases (n = 780 [62%]) were in children <3 years of age. STEC serogroups O26, O80, and O157 accounted for 78% (559/717) of cases with serogroup data. We identified 13 significant space-time clusters and 3 major geographic zones of interest; areas of southeastern France were included in >5 annual space-time clusters. The results of this study have numerous implications for outbreak detection and investigation and research perspectives to improve knowledge of environmental risk factors associated with geographic disparities in STEC-HUS in France. |
format | Online Article Text |
id | pubmed-10521606 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Centers for Disease Control and Prevention |
record_format | MEDLINE/PubMed |
spelling | pubmed-105216062023-10-01 Sporadic Shiga Toxin–Producing Escherichia coli–Associated Pediatric Hemolytic Uremic Syndrome, France, 2012–2021 Jones, Gabrielle Mariani-Kurkdjian, Patricia Cointe, Aurélie Bonacorsi, Stéphane Lefèvre, Sophie Weill, François-Xavier Le Strat, Yann Emerg Infect Dis Research Shiga toxin–producing Escherichia coli–associated pediatric hemolytic uremic syndrome (STEC-HUS) remains an important public health risk in France. Cases are primarily sporadic, and geographic heterogeneity has been observed in crude incidence rates. We conducted a retrospective study of 1,255 sporadic pediatric STEC-HUS cases reported during 2012–2021 to describe spatiotemporal dynamics and geographic patterns of higher STEC-HUS risk. Annual case notifications ranged from 109 to 163. Most cases (n = 780 [62%]) were in children <3 years of age. STEC serogroups O26, O80, and O157 accounted for 78% (559/717) of cases with serogroup data. We identified 13 significant space-time clusters and 3 major geographic zones of interest; areas of southeastern France were included in >5 annual space-time clusters. The results of this study have numerous implications for outbreak detection and investigation and research perspectives to improve knowledge of environmental risk factors associated with geographic disparities in STEC-HUS in France. Centers for Disease Control and Prevention 2023-10 /pmc/articles/PMC10521606/ /pubmed/37735746 http://dx.doi.org/10.3201/eid2910.230382 Text en https://creativecommons.org/licenses/by/4.0/Emerging Infectious Diseases is a publication of the U.S. Government. This publication is in the public domain and is therefore without copyright. All text from this work may be reprinted freely. Use of these materials should be properly cited. |
spellingShingle | Research Jones, Gabrielle Mariani-Kurkdjian, Patricia Cointe, Aurélie Bonacorsi, Stéphane Lefèvre, Sophie Weill, François-Xavier Le Strat, Yann Sporadic Shiga Toxin–Producing Escherichia coli–Associated Pediatric Hemolytic Uremic Syndrome, France, 2012–2021 |
title | Sporadic Shiga Toxin–Producing Escherichia coli–Associated Pediatric Hemolytic Uremic Syndrome, France, 2012–2021 |
title_full | Sporadic Shiga Toxin–Producing Escherichia coli–Associated Pediatric Hemolytic Uremic Syndrome, France, 2012–2021 |
title_fullStr | Sporadic Shiga Toxin–Producing Escherichia coli–Associated Pediatric Hemolytic Uremic Syndrome, France, 2012–2021 |
title_full_unstemmed | Sporadic Shiga Toxin–Producing Escherichia coli–Associated Pediatric Hemolytic Uremic Syndrome, France, 2012–2021 |
title_short | Sporadic Shiga Toxin–Producing Escherichia coli–Associated Pediatric Hemolytic Uremic Syndrome, France, 2012–2021 |
title_sort | sporadic shiga toxin–producing escherichia coli–associated pediatric hemolytic uremic syndrome, france, 2012–2021 |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10521606/ https://www.ncbi.nlm.nih.gov/pubmed/37735746 http://dx.doi.org/10.3201/eid2910.230382 |
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