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Sporadic Shiga Toxin–Producing Escherichia coli–Associated Pediatric Hemolytic Uremic Syndrome, France, 2012–2021

Shiga toxin–producing Escherichia coli–associated pediatric hemolytic uremic syndrome (STEC-HUS) remains an important public health risk in France. Cases are primarily sporadic, and geographic heterogeneity has been observed in crude incidence rates. We conducted a retrospective study of 1,255 spora...

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Autores principales: Jones, Gabrielle, Mariani-Kurkdjian, Patricia, Cointe, Aurélie, Bonacorsi, Stéphane, Lefèvre, Sophie, Weill, François-Xavier, Le Strat, Yann
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Centers for Disease Control and Prevention 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10521606/
https://www.ncbi.nlm.nih.gov/pubmed/37735746
http://dx.doi.org/10.3201/eid2910.230382
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author Jones, Gabrielle
Mariani-Kurkdjian, Patricia
Cointe, Aurélie
Bonacorsi, Stéphane
Lefèvre, Sophie
Weill, François-Xavier
Le Strat, Yann
author_facet Jones, Gabrielle
Mariani-Kurkdjian, Patricia
Cointe, Aurélie
Bonacorsi, Stéphane
Lefèvre, Sophie
Weill, François-Xavier
Le Strat, Yann
author_sort Jones, Gabrielle
collection PubMed
description Shiga toxin–producing Escherichia coli–associated pediatric hemolytic uremic syndrome (STEC-HUS) remains an important public health risk in France. Cases are primarily sporadic, and geographic heterogeneity has been observed in crude incidence rates. We conducted a retrospective study of 1,255 sporadic pediatric STEC-HUS cases reported during 2012–2021 to describe spatiotemporal dynamics and geographic patterns of higher STEC-HUS risk. Annual case notifications ranged from 109 to 163. Most cases (n = 780 [62%]) were in children <3 years of age. STEC serogroups O26, O80, and O157 accounted for 78% (559/717) of cases with serogroup data. We identified 13 significant space-time clusters and 3 major geographic zones of interest; areas of southeastern France were included in >5 annual space-time clusters. The results of this study have numerous implications for outbreak detection and investigation and research perspectives to improve knowledge of environmental risk factors associated with geographic disparities in STEC-HUS in France.
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spelling pubmed-105216062023-10-01 Sporadic Shiga Toxin–Producing Escherichia coli–Associated Pediatric Hemolytic Uremic Syndrome, France, 2012–2021 Jones, Gabrielle Mariani-Kurkdjian, Patricia Cointe, Aurélie Bonacorsi, Stéphane Lefèvre, Sophie Weill, François-Xavier Le Strat, Yann Emerg Infect Dis Research Shiga toxin–producing Escherichia coli–associated pediatric hemolytic uremic syndrome (STEC-HUS) remains an important public health risk in France. Cases are primarily sporadic, and geographic heterogeneity has been observed in crude incidence rates. We conducted a retrospective study of 1,255 sporadic pediatric STEC-HUS cases reported during 2012–2021 to describe spatiotemporal dynamics and geographic patterns of higher STEC-HUS risk. Annual case notifications ranged from 109 to 163. Most cases (n = 780 [62%]) were in children <3 years of age. STEC serogroups O26, O80, and O157 accounted for 78% (559/717) of cases with serogroup data. We identified 13 significant space-time clusters and 3 major geographic zones of interest; areas of southeastern France were included in >5 annual space-time clusters. The results of this study have numerous implications for outbreak detection and investigation and research perspectives to improve knowledge of environmental risk factors associated with geographic disparities in STEC-HUS in France. Centers for Disease Control and Prevention 2023-10 /pmc/articles/PMC10521606/ /pubmed/37735746 http://dx.doi.org/10.3201/eid2910.230382 Text en https://creativecommons.org/licenses/by/4.0/Emerging Infectious Diseases is a publication of the U.S. Government. This publication is in the public domain and is therefore without copyright. All text from this work may be reprinted freely. Use of these materials should be properly cited.
spellingShingle Research
Jones, Gabrielle
Mariani-Kurkdjian, Patricia
Cointe, Aurélie
Bonacorsi, Stéphane
Lefèvre, Sophie
Weill, François-Xavier
Le Strat, Yann
Sporadic Shiga Toxin–Producing Escherichia coli–Associated Pediatric Hemolytic Uremic Syndrome, France, 2012–2021
title Sporadic Shiga Toxin–Producing Escherichia coli–Associated Pediatric Hemolytic Uremic Syndrome, France, 2012–2021
title_full Sporadic Shiga Toxin–Producing Escherichia coli–Associated Pediatric Hemolytic Uremic Syndrome, France, 2012–2021
title_fullStr Sporadic Shiga Toxin–Producing Escherichia coli–Associated Pediatric Hemolytic Uremic Syndrome, France, 2012–2021
title_full_unstemmed Sporadic Shiga Toxin–Producing Escherichia coli–Associated Pediatric Hemolytic Uremic Syndrome, France, 2012–2021
title_short Sporadic Shiga Toxin–Producing Escherichia coli–Associated Pediatric Hemolytic Uremic Syndrome, France, 2012–2021
title_sort sporadic shiga toxin–producing escherichia coli–associated pediatric hemolytic uremic syndrome, france, 2012–2021
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10521606/
https://www.ncbi.nlm.nih.gov/pubmed/37735746
http://dx.doi.org/10.3201/eid2910.230382
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