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Phages and Nanotechnology: New Insights against Multidrug-Resistant Bacteria
Bacterial infections are a major threat to the human healthcare system worldwide, as antibiotics are becoming less effective due to the emergence of multidrug-resistant strains. Therefore, there is a need to explore nontraditional antimicrobial alternatives to support rapid interventions and combat...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
AAAS
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10521656/ https://www.ncbi.nlm.nih.gov/pubmed/37849463 http://dx.doi.org/10.34133/bdr.0004 |
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author | Pardo-Freire, Marco Domingo-Calap, Pilar |
author_facet | Pardo-Freire, Marco Domingo-Calap, Pilar |
author_sort | Pardo-Freire, Marco |
collection | PubMed |
description | Bacterial infections are a major threat to the human healthcare system worldwide, as antibiotics are becoming less effective due to the emergence of multidrug-resistant strains. Therefore, there is a need to explore nontraditional antimicrobial alternatives to support rapid interventions and combat the spread of pathogenic bacteria. New nonantibiotic approaches are being developed, many of them at the interface of physics, nanotechnology, and microbiology. While physical factors (e.g., pressure, temperature, and ultraviolet light) are typically used in the sterilization process, nanoparticles and phages (bacterial viruses) are also applied to combat pathogenic bacteria. Particularly, phage-based therapies are rising due to the unparalleled specificity and high bactericidal activity of phages. Despite the success of phages mostly as compassionate use in clinical cases, some drawbacks need to be addressed, mainly related to their stability, bioavailability, and systemic administration. Combining phages with nanoparticles can improve their performance in vivo. Thus, the combination of nanotechnology and phages might provide tools for the rapid and accurate detection of bacteria in biological samples (diagnosis and typing), and the development of antimicrobials that combine the selectivity of phages with the efficacy of targeted therapy, such as photothermal ablation or photodynamic therapies. In this review, we aim to provide an overview of how phage-based nanotechnology represents a step forward in the fight against multidrug-resistant bacteria. |
format | Online Article Text |
id | pubmed-10521656 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | AAAS |
record_format | MEDLINE/PubMed |
spelling | pubmed-105216562023-10-17 Phages and Nanotechnology: New Insights against Multidrug-Resistant Bacteria Pardo-Freire, Marco Domingo-Calap, Pilar Biodes Res Review Bacterial infections are a major threat to the human healthcare system worldwide, as antibiotics are becoming less effective due to the emergence of multidrug-resistant strains. Therefore, there is a need to explore nontraditional antimicrobial alternatives to support rapid interventions and combat the spread of pathogenic bacteria. New nonantibiotic approaches are being developed, many of them at the interface of physics, nanotechnology, and microbiology. While physical factors (e.g., pressure, temperature, and ultraviolet light) are typically used in the sterilization process, nanoparticles and phages (bacterial viruses) are also applied to combat pathogenic bacteria. Particularly, phage-based therapies are rising due to the unparalleled specificity and high bactericidal activity of phages. Despite the success of phages mostly as compassionate use in clinical cases, some drawbacks need to be addressed, mainly related to their stability, bioavailability, and systemic administration. Combining phages with nanoparticles can improve their performance in vivo. Thus, the combination of nanotechnology and phages might provide tools for the rapid and accurate detection of bacteria in biological samples (diagnosis and typing), and the development of antimicrobials that combine the selectivity of phages with the efficacy of targeted therapy, such as photothermal ablation or photodynamic therapies. In this review, we aim to provide an overview of how phage-based nanotechnology represents a step forward in the fight against multidrug-resistant bacteria. AAAS 2023-01-16 /pmc/articles/PMC10521656/ /pubmed/37849463 http://dx.doi.org/10.34133/bdr.0004 Text en Copyright © 2023 Marco Pardo-Freire and Pilar Domingo-Calap https://creativecommons.org/licenses/by/4.0/Exclusive licensee Nanjing Agricultural University. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution License 4.0 (CC BY 4.0) (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Review Pardo-Freire, Marco Domingo-Calap, Pilar Phages and Nanotechnology: New Insights against Multidrug-Resistant Bacteria |
title | Phages and Nanotechnology: New Insights against Multidrug-Resistant Bacteria |
title_full | Phages and Nanotechnology: New Insights against Multidrug-Resistant Bacteria |
title_fullStr | Phages and Nanotechnology: New Insights against Multidrug-Resistant Bacteria |
title_full_unstemmed | Phages and Nanotechnology: New Insights against Multidrug-Resistant Bacteria |
title_short | Phages and Nanotechnology: New Insights against Multidrug-Resistant Bacteria |
title_sort | phages and nanotechnology: new insights against multidrug-resistant bacteria |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10521656/ https://www.ncbi.nlm.nih.gov/pubmed/37849463 http://dx.doi.org/10.34133/bdr.0004 |
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