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Phages and Nanotechnology: New Insights against Multidrug-Resistant Bacteria

Bacterial infections are a major threat to the human healthcare system worldwide, as antibiotics are becoming less effective due to the emergence of multidrug-resistant strains. Therefore, there is a need to explore nontraditional antimicrobial alternatives to support rapid interventions and combat...

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Detalles Bibliográficos
Autores principales: Pardo-Freire, Marco, Domingo-Calap, Pilar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: AAAS 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10521656/
https://www.ncbi.nlm.nih.gov/pubmed/37849463
http://dx.doi.org/10.34133/bdr.0004
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author Pardo-Freire, Marco
Domingo-Calap, Pilar
author_facet Pardo-Freire, Marco
Domingo-Calap, Pilar
author_sort Pardo-Freire, Marco
collection PubMed
description Bacterial infections are a major threat to the human healthcare system worldwide, as antibiotics are becoming less effective due to the emergence of multidrug-resistant strains. Therefore, there is a need to explore nontraditional antimicrobial alternatives to support rapid interventions and combat the spread of pathogenic bacteria. New nonantibiotic approaches are being developed, many of them at the interface of physics, nanotechnology, and microbiology. While physical factors (e.g., pressure, temperature, and ultraviolet light) are typically used in the sterilization process, nanoparticles and phages (bacterial viruses) are also applied to combat pathogenic bacteria. Particularly, phage-based therapies are rising due to the unparalleled specificity and high bactericidal activity of phages. Despite the success of phages mostly as compassionate use in clinical cases, some drawbacks need to be addressed, mainly related to their stability, bioavailability, and systemic administration. Combining phages with nanoparticles can improve their performance in vivo. Thus, the combination of nanotechnology and phages might provide tools for the rapid and accurate detection of bacteria in biological samples (diagnosis and typing), and the development of antimicrobials that combine the selectivity of phages with the efficacy of targeted therapy, such as photothermal ablation or photodynamic therapies. In this review, we aim to provide an overview of how phage-based nanotechnology represents a step forward in the fight against multidrug-resistant bacteria.
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spelling pubmed-105216562023-10-17 Phages and Nanotechnology: New Insights against Multidrug-Resistant Bacteria Pardo-Freire, Marco Domingo-Calap, Pilar Biodes Res Review Bacterial infections are a major threat to the human healthcare system worldwide, as antibiotics are becoming less effective due to the emergence of multidrug-resistant strains. Therefore, there is a need to explore nontraditional antimicrobial alternatives to support rapid interventions and combat the spread of pathogenic bacteria. New nonantibiotic approaches are being developed, many of them at the interface of physics, nanotechnology, and microbiology. While physical factors (e.g., pressure, temperature, and ultraviolet light) are typically used in the sterilization process, nanoparticles and phages (bacterial viruses) are also applied to combat pathogenic bacteria. Particularly, phage-based therapies are rising due to the unparalleled specificity and high bactericidal activity of phages. Despite the success of phages mostly as compassionate use in clinical cases, some drawbacks need to be addressed, mainly related to their stability, bioavailability, and systemic administration. Combining phages with nanoparticles can improve their performance in vivo. Thus, the combination of nanotechnology and phages might provide tools for the rapid and accurate detection of bacteria in biological samples (diagnosis and typing), and the development of antimicrobials that combine the selectivity of phages with the efficacy of targeted therapy, such as photothermal ablation or photodynamic therapies. In this review, we aim to provide an overview of how phage-based nanotechnology represents a step forward in the fight against multidrug-resistant bacteria. AAAS 2023-01-16 /pmc/articles/PMC10521656/ /pubmed/37849463 http://dx.doi.org/10.34133/bdr.0004 Text en Copyright © 2023 Marco Pardo-Freire and Pilar Domingo-Calap https://creativecommons.org/licenses/by/4.0/Exclusive licensee Nanjing Agricultural University. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution License 4.0 (CC BY 4.0) (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Review
Pardo-Freire, Marco
Domingo-Calap, Pilar
Phages and Nanotechnology: New Insights against Multidrug-Resistant Bacteria
title Phages and Nanotechnology: New Insights against Multidrug-Resistant Bacteria
title_full Phages and Nanotechnology: New Insights against Multidrug-Resistant Bacteria
title_fullStr Phages and Nanotechnology: New Insights against Multidrug-Resistant Bacteria
title_full_unstemmed Phages and Nanotechnology: New Insights against Multidrug-Resistant Bacteria
title_short Phages and Nanotechnology: New Insights against Multidrug-Resistant Bacteria
title_sort phages and nanotechnology: new insights against multidrug-resistant bacteria
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10521656/
https://www.ncbi.nlm.nih.gov/pubmed/37849463
http://dx.doi.org/10.34133/bdr.0004
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