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Perspective: The Rapidly Expanding Need for Biosecurity by Design
Advancing biotechnologies are revolutionizing not only health and medicine, but also many different sectors such as agriculture, energy, chemistry, and textiles. As synthetic biology is leveraged as a programmable platform for the creation and biodesign of high-value biological medicines, foods, and...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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AAAS
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10521668/ https://www.ncbi.nlm.nih.gov/pubmed/37850149 http://dx.doi.org/10.34133/2022/9809058 |
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author | DiEuliis, Diane |
author_facet | DiEuliis, Diane |
author_sort | DiEuliis, Diane |
collection | PubMed |
description | Advancing biotechnologies are revolutionizing not only health and medicine, but also many different sectors such as agriculture, energy, chemistry, and textiles. As synthetic biology is leveraged as a programmable platform for the creation and biodesign of high-value biological medicines, foods, and commodities, the world is facing new territory in terms of ensuring the safety and security of both novel and engineered biological organisms, as well as the biological and digital platforms in which they are designed. Biosecurity practices and policies have traditionally revolved around preventing the misuse of biological pathogens, primarily through controlling access to pathogens. The advent of biodesign capabilities, such as gene editors, gene synthesis capabilities, and genetic engineering, requires a reevaluation of traditional biosecurity policies to mitigate risks associated with such engineering of biological entities. Here, features of “Biosecurity by Design” approaches are described, including the application of risk/benefit analysis and risk mitigation, post-COVID opportunities, and ethical global norms in the progression of biodesign and growing bioeconomies. |
format | Online Article Text |
id | pubmed-10521668 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | AAAS |
record_format | MEDLINE/PubMed |
spelling | pubmed-105216682023-10-17 Perspective: The Rapidly Expanding Need for Biosecurity by Design DiEuliis, Diane Biodes Res Perspective Advancing biotechnologies are revolutionizing not only health and medicine, but also many different sectors such as agriculture, energy, chemistry, and textiles. As synthetic biology is leveraged as a programmable platform for the creation and biodesign of high-value biological medicines, foods, and commodities, the world is facing new territory in terms of ensuring the safety and security of both novel and engineered biological organisms, as well as the biological and digital platforms in which they are designed. Biosecurity practices and policies have traditionally revolved around preventing the misuse of biological pathogens, primarily through controlling access to pathogens. The advent of biodesign capabilities, such as gene editors, gene synthesis capabilities, and genetic engineering, requires a reevaluation of traditional biosecurity policies to mitigate risks associated with such engineering of biological entities. Here, features of “Biosecurity by Design” approaches are described, including the application of risk/benefit analysis and risk mitigation, post-COVID opportunities, and ethical global norms in the progression of biodesign and growing bioeconomies. AAAS 2022-05-25 /pmc/articles/PMC10521668/ /pubmed/37850149 http://dx.doi.org/10.34133/2022/9809058 Text en Copyright © 2022 Diane DiEuliis. https://creativecommons.org/licenses/by/4.0/Exclusive Licensee Nanjing Agricultural University. Distributed under a Creative Commons Attribution License (CC BY 4.0). (https://creativecommons.org/licenses/by/4.0/) |
spellingShingle | Perspective DiEuliis, Diane Perspective: The Rapidly Expanding Need for Biosecurity by Design |
title | Perspective: The Rapidly Expanding Need for Biosecurity by Design |
title_full | Perspective: The Rapidly Expanding Need for Biosecurity by Design |
title_fullStr | Perspective: The Rapidly Expanding Need for Biosecurity by Design |
title_full_unstemmed | Perspective: The Rapidly Expanding Need for Biosecurity by Design |
title_short | Perspective: The Rapidly Expanding Need for Biosecurity by Design |
title_sort | perspective: the rapidly expanding need for biosecurity by design |
topic | Perspective |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10521668/ https://www.ncbi.nlm.nih.gov/pubmed/37850149 http://dx.doi.org/10.34133/2022/9809058 |
work_keys_str_mv | AT dieuliisdiane perspectivetherapidlyexpandingneedforbiosecuritybydesign |