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Tissue Engineering in Neuroscience: Applications and Perspectives
Neurological disorders have always been a threat to human physical and mental health nowadays, which are closely related to the nonregeneration of neurons in the nervous system (NS). The damage to the NS is currently difficult to repair using conventional therapies, such as surgery and medication. T...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
AAAS
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10521717/ https://www.ncbi.nlm.nih.gov/pubmed/37849680 http://dx.doi.org/10.34133/bmef.0007 |
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author | Zhang, Xiaoge Liu, Fuyao Gu, Zhen |
author_facet | Zhang, Xiaoge Liu, Fuyao Gu, Zhen |
author_sort | Zhang, Xiaoge |
collection | PubMed |
description | Neurological disorders have always been a threat to human physical and mental health nowadays, which are closely related to the nonregeneration of neurons in the nervous system (NS). The damage to the NS is currently difficult to repair using conventional therapies, such as surgery and medication. Therefore, repairing the damaged NS has always been a vast challenge in the area of neurology. Tissue engineering (TE), which integrates the cell biology and materials science to reconstruct or repair organs and tissues, has widespread applications in bone, periodontal tissue defects, skin repairs, and corneal transplantation. Recently, tremendous advances have been made in TE regarding neuroscience. In this review, we summarize TE’s recent progress in neuroscience, including pathological mechanisms of various neurological disorders, the concepts and classification of TE, and the most recent development of TE in neuroscience. Lastly, we prospect the future directions and unresolved problems of TE in neuroscience. |
format | Online Article Text |
id | pubmed-10521717 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | AAAS |
record_format | MEDLINE/PubMed |
spelling | pubmed-105217172023-10-17 Tissue Engineering in Neuroscience: Applications and Perspectives Zhang, Xiaoge Liu, Fuyao Gu, Zhen BME Front Review Neurological disorders have always been a threat to human physical and mental health nowadays, which are closely related to the nonregeneration of neurons in the nervous system (NS). The damage to the NS is currently difficult to repair using conventional therapies, such as surgery and medication. Therefore, repairing the damaged NS has always been a vast challenge in the area of neurology. Tissue engineering (TE), which integrates the cell biology and materials science to reconstruct or repair organs and tissues, has widespread applications in bone, periodontal tissue defects, skin repairs, and corneal transplantation. Recently, tremendous advances have been made in TE regarding neuroscience. In this review, we summarize TE’s recent progress in neuroscience, including pathological mechanisms of various neurological disorders, the concepts and classification of TE, and the most recent development of TE in neuroscience. Lastly, we prospect the future directions and unresolved problems of TE in neuroscience. AAAS 2023-01-16 /pmc/articles/PMC10521717/ /pubmed/37849680 http://dx.doi.org/10.34133/bmef.0007 Text en Copyright © 2023 Xiaoge Zhang et al. https://creativecommons.org/licenses/by/4.0/Exclusive licensee Suzhou Institute of Biomedical Engineering and Technology, CAS. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution License 4.0 (CC BY 4.0) (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Review Zhang, Xiaoge Liu, Fuyao Gu, Zhen Tissue Engineering in Neuroscience: Applications and Perspectives |
title | Tissue Engineering in Neuroscience: Applications and Perspectives |
title_full | Tissue Engineering in Neuroscience: Applications and Perspectives |
title_fullStr | Tissue Engineering in Neuroscience: Applications and Perspectives |
title_full_unstemmed | Tissue Engineering in Neuroscience: Applications and Perspectives |
title_short | Tissue Engineering in Neuroscience: Applications and Perspectives |
title_sort | tissue engineering in neuroscience: applications and perspectives |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10521717/ https://www.ncbi.nlm.nih.gov/pubmed/37849680 http://dx.doi.org/10.34133/bmef.0007 |
work_keys_str_mv | AT zhangxiaoge tissueengineeringinneuroscienceapplicationsandperspectives AT liufuyao tissueengineeringinneuroscienceapplicationsandperspectives AT guzhen tissueengineeringinneuroscienceapplicationsandperspectives |