Essential role of the mitochondrial Na(+)/Ca(2+) exchanger NCLX in mediating PDE2-dependent neuronal survival and learning

Impaired phosphodiesterase (PDE) function and mitochondrial Ca(2+) (i.e., [Ca(2+)]m) lead to multiple health syndromes by an unknown pathway. Here, we fluorescently monitor robust [Ca(2+)]m efflux mediated by the mitochondrial Na(+)/Ca(2+) exchanger NCLX in hippocampal neurons sequentially evoked by...

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Detalles Bibliográficos
Autores principales: Rozenfeld, Maya, Azoulay, Ivana Savic, Nissim, Tsipi Ben Kasus, Stavsky, Alexandra, Melamed, Moran, Stutzmann, Grace, Hershfinkel, Michal, Kofman, Ora, Sekler, Israel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10521900/
https://www.ncbi.nlm.nih.gov/pubmed/36476859
http://dx.doi.org/10.1016/j.celrep.2022.111772

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