PCDH12 loss results in premature neuronal differentiation and impeded migration in a cortical organoid model

Protocadherins (PCDHs) are cell adhesion molecules that regulate many essential neurodevelopmental processes related to neuronal maturation, dendritic arbor formation, axon pathfinding, and synaptic plasticity. Biallelic loss-of-function variants in PCDH12 are associated with several neurodevelopmen...

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Detalles Bibliográficos
Autores principales: Rakotomamonjy, Jennifer, Rylaarsdam, Lauren, Fares-Taie, Lucas, McDermott, Sean, Davies, Devin, Yang, George, Fagbemi, Fikayo, Epstein, Maya, Fairbanks-Santana, Martín, Rozet, Jean-Michel, Guemez-Gamboa, Alicia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10521973/
https://www.ncbi.nlm.nih.gov/pubmed/37480564
http://dx.doi.org/10.1016/j.celrep.2023.112845

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10521973/
https://www.ncbi.nlm.nih.gov/pubmed/37480564
http://dx.doi.org/10.1016/j.celrep.2023.112845

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