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PCDH12 loss results in premature neuronal differentiation and impeded migration in a cortical organoid model
Protocadherins (PCDHs) are cell adhesion molecules that regulate many essential neurodevelopmental processes related to neuronal maturation, dendritic arbor formation, axon pathfinding, and synaptic plasticity. Biallelic loss-of-function variants in PCDH12 are associated with several neurodevelopmen...
| Autores principales: | , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10521973/ https://www.ncbi.nlm.nih.gov/pubmed/37480564 http://dx.doi.org/10.1016/j.celrep.2023.112845 |