Cargando…
High prevalence of insulin resistance among Brazilian chronic hepatitis C patients
OBJECTIVE: This study aims to estimate the prevalence of insulin resistance (IR) among chronic hepatitis C (CHC) patients and their related laboratory and demographic data. SUBJECTS AND METHODS: In this study, non-diabetic CHC patients referred to Viral Hepatitis Ambulatories from Rio de Janeiro (Br...
Autores principales: | , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Sociedade Brasileira de Endocrinologia e Metabologia
2017
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10522051/ https://www.ncbi.nlm.nih.gov/pubmed/29412389 http://dx.doi.org/10.1590/2359-3997000000315 |
_version_ | 1785110274264530944 |
---|---|
author | Villar, Livia Melo Caldas, Gabriela Cardoso Scalioni, Leticia de Paula Miguel, Juliana Custódio da Silva, Elisangela Ferreira Marques, Vanessa Alves Villela-Nogueira, Cristiane Alves Lewis-Ximenez, Lia Laura Lampe, Elisabeth |
author_facet | Villar, Livia Melo Caldas, Gabriela Cardoso Scalioni, Leticia de Paula Miguel, Juliana Custódio da Silva, Elisangela Ferreira Marques, Vanessa Alves Villela-Nogueira, Cristiane Alves Lewis-Ximenez, Lia Laura Lampe, Elisabeth |
author_sort | Villar, Livia Melo |
collection | PubMed |
description | OBJECTIVE: This study aims to estimate the prevalence of insulin resistance (IR) among chronic hepatitis C (CHC) patients and their related laboratory and demographic data. SUBJECTS AND METHODS: In this study, non-diabetic CHC patients referred to Viral Hepatitis Ambulatories from Rio de Janeiro (Brazil) donated blood samples. Insulin was measured using a chemiluminescence immunoassay. IR was determined by HOMA-IR, where HOMA-IR > 2 was defined as IR. RESULTS: A total of 214 CHC patients were recruited (123 females aged 53.6 years ± 10.9 years). IR was present in 133 patients (62.1%) and was associated in bivariate analysis to higher mean values of age (p = 0.040), triglycerides (p = 0.032), glucose (p = 0.000), insulin (p = 0.000), waist circumference (p = 0.001), and body mass index (p = 0.007); however, none of these variables were significant in the multivariate analysis. CONCLUSIONS: The high prevalence of IR was observed among CHC patients, and there was no difference in clinical or laboratory parameters when both groups were compared in the multivariate analysis. This high IR prevalence could lead to a high risk for development of cardiovascular disease and metabolic disorders. |
format | Online Article Text |
id | pubmed-10522051 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Sociedade Brasileira de Endocrinologia e Metabologia |
record_format | MEDLINE/PubMed |
spelling | pubmed-105220512023-09-27 High prevalence of insulin resistance among Brazilian chronic hepatitis C patients Villar, Livia Melo Caldas, Gabriela Cardoso Scalioni, Leticia de Paula Miguel, Juliana Custódio da Silva, Elisangela Ferreira Marques, Vanessa Alves Villela-Nogueira, Cristiane Alves Lewis-Ximenez, Lia Laura Lampe, Elisabeth Arch Endocrinol Metab Brief Report OBJECTIVE: This study aims to estimate the prevalence of insulin resistance (IR) among chronic hepatitis C (CHC) patients and their related laboratory and demographic data. SUBJECTS AND METHODS: In this study, non-diabetic CHC patients referred to Viral Hepatitis Ambulatories from Rio de Janeiro (Brazil) donated blood samples. Insulin was measured using a chemiluminescence immunoassay. IR was determined by HOMA-IR, where HOMA-IR > 2 was defined as IR. RESULTS: A total of 214 CHC patients were recruited (123 females aged 53.6 years ± 10.9 years). IR was present in 133 patients (62.1%) and was associated in bivariate analysis to higher mean values of age (p = 0.040), triglycerides (p = 0.032), glucose (p = 0.000), insulin (p = 0.000), waist circumference (p = 0.001), and body mass index (p = 0.007); however, none of these variables were significant in the multivariate analysis. CONCLUSIONS: The high prevalence of IR was observed among CHC patients, and there was no difference in clinical or laboratory parameters when both groups were compared in the multivariate analysis. This high IR prevalence could lead to a high risk for development of cardiovascular disease and metabolic disorders. Sociedade Brasileira de Endocrinologia e Metabologia 2017-12-01 /pmc/articles/PMC10522051/ /pubmed/29412389 http://dx.doi.org/10.1590/2359-3997000000315 Text en https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Brief Report Villar, Livia Melo Caldas, Gabriela Cardoso Scalioni, Leticia de Paula Miguel, Juliana Custódio da Silva, Elisangela Ferreira Marques, Vanessa Alves Villela-Nogueira, Cristiane Alves Lewis-Ximenez, Lia Laura Lampe, Elisabeth High prevalence of insulin resistance among Brazilian chronic hepatitis C patients |
title | High prevalence of insulin resistance among Brazilian chronic hepatitis C patients |
title_full | High prevalence of insulin resistance among Brazilian chronic hepatitis C patients |
title_fullStr | High prevalence of insulin resistance among Brazilian chronic hepatitis C patients |
title_full_unstemmed | High prevalence of insulin resistance among Brazilian chronic hepatitis C patients |
title_short | High prevalence of insulin resistance among Brazilian chronic hepatitis C patients |
title_sort | high prevalence of insulin resistance among brazilian chronic hepatitis c patients |
topic | Brief Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10522051/ https://www.ncbi.nlm.nih.gov/pubmed/29412389 http://dx.doi.org/10.1590/2359-3997000000315 |
work_keys_str_mv | AT villarliviamelo highprevalenceofinsulinresistanceamongbrazilianchronichepatitiscpatients AT caldasgabrielacardoso highprevalenceofinsulinresistanceamongbrazilianchronichepatitiscpatients AT scalionileticiadepaula highprevalenceofinsulinresistanceamongbrazilianchronichepatitiscpatients AT migueljulianacustodio highprevalenceofinsulinresistanceamongbrazilianchronichepatitiscpatients AT dasilvaelisangelaferreira highprevalenceofinsulinresistanceamongbrazilianchronichepatitiscpatients AT marquesvanessaalves highprevalenceofinsulinresistanceamongbrazilianchronichepatitiscpatients AT villelanogueiracristianealves highprevalenceofinsulinresistanceamongbrazilianchronichepatitiscpatients AT lewisximenezlialaura highprevalenceofinsulinresistanceamongbrazilianchronichepatitiscpatients AT lampeelisabeth highprevalenceofinsulinresistanceamongbrazilianchronichepatitiscpatients |