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Metastatic lymph node characteristics as predictors of recurrence/persistence in the neck and distant metastases in differentiated thyroid cancer

OBJECTIVE: The aim of this study was to evaluate the association between this characteristic and outcomes in patients with lymph node metastasis in a Brazilian cohort. SUBJECTS AND METHODS: This study examined a retrospective cohort of adult patients diagnosed with differentiated thyroid cancer and...

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Autores principales: Barbosa, Mayara Peres, Momesso, Denise, Bulzico, Daniel Alves, Farias, Terence, Dias, Fernando, Lima, Roberto Araújo, Corbo, Rossana, Vaisman, Mario, Vaisman, Fernanda
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Sociedade Brasileira de Endocrinologia e Metabologia 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10522061/
https://www.ncbi.nlm.nih.gov/pubmed/29412383
http://dx.doi.org/10.1590/2359-3997000000307
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author Barbosa, Mayara Peres
Momesso, Denise
Bulzico, Daniel Alves
Farias, Terence
Dias, Fernando
Lima, Roberto Araújo
Corbo, Rossana
Vaisman, Mario
Vaisman, Fernanda
author_facet Barbosa, Mayara Peres
Momesso, Denise
Bulzico, Daniel Alves
Farias, Terence
Dias, Fernando
Lima, Roberto Araújo
Corbo, Rossana
Vaisman, Mario
Vaisman, Fernanda
author_sort Barbosa, Mayara Peres
collection PubMed
description OBJECTIVE: The aim of this study was to evaluate the association between this characteristic and outcomes in patients with lymph node metastasis in a Brazilian cohort. SUBJECTS AND METHODS: This study examined a retrospective cohort of adult patients diagnosed with differentiated thyroid cancer and lymph node metastases from 1998 to 2015 in two referral centers. Number, location, size and extranodal extension (ENE) of metastatic lymph nodes were assessed and correlated with response to initial therapy. RESULTS: A greater number of metastatic nodes, larger size, presence of lateral neck disease and ENE were all associated with a lower probability of achieving an excellent response to initial therapy (p ≤ 0.05 for all these parameters). Local recurrent disease had a significant association with lymph node number (6 in the recurrence/persistence group versus 4 in the non-recurrent group; p = 0.02) and ENE (19.2 versus 75%, p = 0.03). Lateral neck disease was the only characteristic associated with distant metastasis and was present in 52.1% of the group without metastasis and 70.4% of the group with metastasis (p = 0.001). CONCLUSION: The lymph node characteristics were associated with response to initial therapy and neck recurrence/persistence, confirming the importance of the analysis of these factors in risk stratification in a Brazilian population and its possible use to tailor initial staging and long term follow-up.
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spelling pubmed-105220612023-09-27 Metastatic lymph node characteristics as predictors of recurrence/persistence in the neck and distant metastases in differentiated thyroid cancer Barbosa, Mayara Peres Momesso, Denise Bulzico, Daniel Alves Farias, Terence Dias, Fernando Lima, Roberto Araújo Corbo, Rossana Vaisman, Mario Vaisman, Fernanda Arch Endocrinol Metab Original Article OBJECTIVE: The aim of this study was to evaluate the association between this characteristic and outcomes in patients with lymph node metastasis in a Brazilian cohort. SUBJECTS AND METHODS: This study examined a retrospective cohort of adult patients diagnosed with differentiated thyroid cancer and lymph node metastases from 1998 to 2015 in two referral centers. Number, location, size and extranodal extension (ENE) of metastatic lymph nodes were assessed and correlated with response to initial therapy. RESULTS: A greater number of metastatic nodes, larger size, presence of lateral neck disease and ENE were all associated with a lower probability of achieving an excellent response to initial therapy (p ≤ 0.05 for all these parameters). Local recurrent disease had a significant association with lymph node number (6 in the recurrence/persistence group versus 4 in the non-recurrent group; p = 0.02) and ENE (19.2 versus 75%, p = 0.03). Lateral neck disease was the only characteristic associated with distant metastasis and was present in 52.1% of the group without metastasis and 70.4% of the group with metastasis (p = 0.001). CONCLUSION: The lymph node characteristics were associated with response to initial therapy and neck recurrence/persistence, confirming the importance of the analysis of these factors in risk stratification in a Brazilian population and its possible use to tailor initial staging and long term follow-up. Sociedade Brasileira de Endocrinologia e Metabologia 2017-12-01 /pmc/articles/PMC10522061/ /pubmed/29412383 http://dx.doi.org/10.1590/2359-3997000000307 Text en https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Barbosa, Mayara Peres
Momesso, Denise
Bulzico, Daniel Alves
Farias, Terence
Dias, Fernando
Lima, Roberto Araújo
Corbo, Rossana
Vaisman, Mario
Vaisman, Fernanda
Metastatic lymph node characteristics as predictors of recurrence/persistence in the neck and distant metastases in differentiated thyroid cancer
title Metastatic lymph node characteristics as predictors of recurrence/persistence in the neck and distant metastases in differentiated thyroid cancer
title_full Metastatic lymph node characteristics as predictors of recurrence/persistence in the neck and distant metastases in differentiated thyroid cancer
title_fullStr Metastatic lymph node characteristics as predictors of recurrence/persistence in the neck and distant metastases in differentiated thyroid cancer
title_full_unstemmed Metastatic lymph node characteristics as predictors of recurrence/persistence in the neck and distant metastases in differentiated thyroid cancer
title_short Metastatic lymph node characteristics as predictors of recurrence/persistence in the neck and distant metastases in differentiated thyroid cancer
title_sort metastatic lymph node characteristics as predictors of recurrence/persistence in the neck and distant metastases in differentiated thyroid cancer
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10522061/
https://www.ncbi.nlm.nih.gov/pubmed/29412383
http://dx.doi.org/10.1590/2359-3997000000307
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