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Prognostic value of lactate dehydrogenase in patients with uveal melanoma treated with immune checkpoint inhibition
Objective: We performed the meta-analysis to explore the predictive value of lactate dehydrogenase (LDH) levels in uveal melanoma (UM) patients receiving immune checkpoint inhibitors (ICIs). Methods: Eligible articles were obtained through EMBASE, PubMed, Google Scholar, and the Cochrane Library, un...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10522394/ https://www.ncbi.nlm.nih.gov/pubmed/37671944 http://dx.doi.org/10.18632/aging.204996 |
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author | Liang, Xiaocui Zhou, Shan Xiao, Zefeng |
author_facet | Liang, Xiaocui Zhou, Shan Xiao, Zefeng |
author_sort | Liang, Xiaocui |
collection | PubMed |
description | Objective: We performed the meta-analysis to explore the predictive value of lactate dehydrogenase (LDH) levels in uveal melanoma (UM) patients receiving immune checkpoint inhibitors (ICIs). Methods: Eligible articles were obtained through EMBASE, PubMed, Google Scholar, and the Cochrane Library, until March 23, 2023. The clinical outcomes evaluated in this study encompassed overall survival (OS) and progression-free survival (PFS). Results: This meta-analysis comprised eight studies with a combined total of 383 patients. The results showed that patients with high LDH levels had noticeably worse OS (HR: 3.445, 95% CI: 2.504-4.740, p < 0.001) and PFS (HR: 1.720, 95% CI: 1.429-2.070, p < 0.001). Subgroup analysis confirmed that the upper limit of normal was the ideal cut-off value for LDH. In multivariate analysis, we also found that high LDH levels significantly predicted shorter OS (HR: 3.405, 95% CI: 1.827-6.348, p < 0.001) and PFS (HR: 2.519, 95% CI: 1.557-4.076, p < 0.001) in UM patients. The sensitivity analysis and publication bias test supported the reliability of our results. Conclusions: In UM patients treated with ICIs, the LDH levels were reliable indicators of prognosis. |
format | Online Article Text |
id | pubmed-10522394 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Impact Journals |
record_format | MEDLINE/PubMed |
spelling | pubmed-105223942023-09-27 Prognostic value of lactate dehydrogenase in patients with uveal melanoma treated with immune checkpoint inhibition Liang, Xiaocui Zhou, Shan Xiao, Zefeng Aging (Albany NY) Research Paper Objective: We performed the meta-analysis to explore the predictive value of lactate dehydrogenase (LDH) levels in uveal melanoma (UM) patients receiving immune checkpoint inhibitors (ICIs). Methods: Eligible articles were obtained through EMBASE, PubMed, Google Scholar, and the Cochrane Library, until March 23, 2023. The clinical outcomes evaluated in this study encompassed overall survival (OS) and progression-free survival (PFS). Results: This meta-analysis comprised eight studies with a combined total of 383 patients. The results showed that patients with high LDH levels had noticeably worse OS (HR: 3.445, 95% CI: 2.504-4.740, p < 0.001) and PFS (HR: 1.720, 95% CI: 1.429-2.070, p < 0.001). Subgroup analysis confirmed that the upper limit of normal was the ideal cut-off value for LDH. In multivariate analysis, we also found that high LDH levels significantly predicted shorter OS (HR: 3.405, 95% CI: 1.827-6.348, p < 0.001) and PFS (HR: 2.519, 95% CI: 1.557-4.076, p < 0.001) in UM patients. The sensitivity analysis and publication bias test supported the reliability of our results. Conclusions: In UM patients treated with ICIs, the LDH levels were reliable indicators of prognosis. Impact Journals 2023-09-05 /pmc/articles/PMC10522394/ /pubmed/37671944 http://dx.doi.org/10.18632/aging.204996 Text en Copyright: © 2023 Liang et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/3.0/) (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Paper Liang, Xiaocui Zhou, Shan Xiao, Zefeng Prognostic value of lactate dehydrogenase in patients with uveal melanoma treated with immune checkpoint inhibition |
title | Prognostic value of lactate dehydrogenase in patients with uveal melanoma treated with immune checkpoint inhibition |
title_full | Prognostic value of lactate dehydrogenase in patients with uveal melanoma treated with immune checkpoint inhibition |
title_fullStr | Prognostic value of lactate dehydrogenase in patients with uveal melanoma treated with immune checkpoint inhibition |
title_full_unstemmed | Prognostic value of lactate dehydrogenase in patients with uveal melanoma treated with immune checkpoint inhibition |
title_short | Prognostic value of lactate dehydrogenase in patients with uveal melanoma treated with immune checkpoint inhibition |
title_sort | prognostic value of lactate dehydrogenase in patients with uveal melanoma treated with immune checkpoint inhibition |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10522394/ https://www.ncbi.nlm.nih.gov/pubmed/37671944 http://dx.doi.org/10.18632/aging.204996 |
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