Cargando…
Childhood maltreatment and leukocyte telomere length in men and women with chronic illness: an evaluation of moderating and mediating influences
BACKGROUND: Childhood maltreatment can result in lifelong psychological and physical sequelae, including coronary artery disease (CAD). Mechanisms leading to increased risk of illness may involve emotional dysregulation and shortened leukocyte telomere length (LTL). METHODS: To evaluate whether (1)...
Autores principales: | , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cambridge University Press
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10522448/ https://www.ncbi.nlm.nih.gov/pubmed/36943406 http://dx.doi.org/10.1017/S0033291722003543 |
_version_ | 1785110356807385088 |
---|---|
author | Connor, Alexandra Starnino, Louisia Busque, Lambert Tardif, Jean-Claude Bourgoin, Vincent Dubé, Marie-Pierre Busseuil, David D'Antono, Bianca |
author_facet | Connor, Alexandra Starnino, Louisia Busque, Lambert Tardif, Jean-Claude Bourgoin, Vincent Dubé, Marie-Pierre Busseuil, David D'Antono, Bianca |
author_sort | Connor, Alexandra |
collection | PubMed |
description | BACKGROUND: Childhood maltreatment can result in lifelong psychological and physical sequelae, including coronary artery disease (CAD). Mechanisms leading to increased risk of illness may involve emotional dysregulation and shortened leukocyte telomere length (LTL). METHODS: To evaluate whether (1) childhood maltreatment is associated with shorter LTL among older adults with CAD or other chronic illnesses; (2) sex and/or CAD status influence these results; and (3) symptoms of anxiety, depression, and stress moderate or mediate the association between childhood maltreatment and LTL, men and women (N = 1247; aged 65 ± 7.2 years) with and without CAD completed validated questionnaires on childhood maltreatment, symptoms of depression, anxiety, and perceived stress. LTL was measured using quantitative polymerase chain reaction. Analyses included bivariate correlations, hierarchical regressions, and moderation/mediation analyses, controlling for sociodemographic and lifestyle variables. RESULTS: Childhood maltreatment was associated with significantly shorter LTL (r = −0.059, p = 0.038, b = −0.016, p = 0.005). This relation was not moderated by depression, anxiety, nor perceived stress, though there was mitigated evidence for absence of a maltreatment-LTL relation in men with CAD. Stress perception (but not anxiety or depression) partially mediated the relation between childhood maltreatment and LTL [Indirect effect, b = −0.0041, s.e. = 0.002, 95% CI (−0.0085 to −0.0002)]. CONCLUSIONS: Childhood maltreatment was associated with accelerated biological aging independently of patient characteristics. Emotional dysregulation resulting in chronic stress may contribute to this process. Whether stress management or other interventions may help prevent or slow premature aging in those who have suffered maltreatment requires study. |
format | Online Article Text |
id | pubmed-10522448 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Cambridge University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-105224482023-09-28 Childhood maltreatment and leukocyte telomere length in men and women with chronic illness: an evaluation of moderating and mediating influences Connor, Alexandra Starnino, Louisia Busque, Lambert Tardif, Jean-Claude Bourgoin, Vincent Dubé, Marie-Pierre Busseuil, David D'Antono, Bianca Psychol Med Original Article BACKGROUND: Childhood maltreatment can result in lifelong psychological and physical sequelae, including coronary artery disease (CAD). Mechanisms leading to increased risk of illness may involve emotional dysregulation and shortened leukocyte telomere length (LTL). METHODS: To evaluate whether (1) childhood maltreatment is associated with shorter LTL among older adults with CAD or other chronic illnesses; (2) sex and/or CAD status influence these results; and (3) symptoms of anxiety, depression, and stress moderate or mediate the association between childhood maltreatment and LTL, men and women (N = 1247; aged 65 ± 7.2 years) with and without CAD completed validated questionnaires on childhood maltreatment, symptoms of depression, anxiety, and perceived stress. LTL was measured using quantitative polymerase chain reaction. Analyses included bivariate correlations, hierarchical regressions, and moderation/mediation analyses, controlling for sociodemographic and lifestyle variables. RESULTS: Childhood maltreatment was associated with significantly shorter LTL (r = −0.059, p = 0.038, b = −0.016, p = 0.005). This relation was not moderated by depression, anxiety, nor perceived stress, though there was mitigated evidence for absence of a maltreatment-LTL relation in men with CAD. Stress perception (but not anxiety or depression) partially mediated the relation between childhood maltreatment and LTL [Indirect effect, b = −0.0041, s.e. = 0.002, 95% CI (−0.0085 to −0.0002)]. CONCLUSIONS: Childhood maltreatment was associated with accelerated biological aging independently of patient characteristics. Emotional dysregulation resulting in chronic stress may contribute to this process. Whether stress management or other interventions may help prevent or slow premature aging in those who have suffered maltreatment requires study. Cambridge University Press 2023-10 2022-11-24 /pmc/articles/PMC10522448/ /pubmed/36943406 http://dx.doi.org/10.1017/S0033291722003543 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution and reproduction, provided the original article is properly cited. |
spellingShingle | Original Article Connor, Alexandra Starnino, Louisia Busque, Lambert Tardif, Jean-Claude Bourgoin, Vincent Dubé, Marie-Pierre Busseuil, David D'Antono, Bianca Childhood maltreatment and leukocyte telomere length in men and women with chronic illness: an evaluation of moderating and mediating influences |
title | Childhood maltreatment and leukocyte telomere length in men and women with chronic illness: an evaluation of moderating and mediating influences |
title_full | Childhood maltreatment and leukocyte telomere length in men and women with chronic illness: an evaluation of moderating and mediating influences |
title_fullStr | Childhood maltreatment and leukocyte telomere length in men and women with chronic illness: an evaluation of moderating and mediating influences |
title_full_unstemmed | Childhood maltreatment and leukocyte telomere length in men and women with chronic illness: an evaluation of moderating and mediating influences |
title_short | Childhood maltreatment and leukocyte telomere length in men and women with chronic illness: an evaluation of moderating and mediating influences |
title_sort | childhood maltreatment and leukocyte telomere length in men and women with chronic illness: an evaluation of moderating and mediating influences |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10522448/ https://www.ncbi.nlm.nih.gov/pubmed/36943406 http://dx.doi.org/10.1017/S0033291722003543 |
work_keys_str_mv | AT connoralexandra childhoodmaltreatmentandleukocytetelomerelengthinmenandwomenwithchronicillnessanevaluationofmoderatingandmediatinginfluences AT starninolouisia childhoodmaltreatmentandleukocytetelomerelengthinmenandwomenwithchronicillnessanevaluationofmoderatingandmediatinginfluences AT busquelambert childhoodmaltreatmentandleukocytetelomerelengthinmenandwomenwithchronicillnessanevaluationofmoderatingandmediatinginfluences AT tardifjeanclaude childhoodmaltreatmentandleukocytetelomerelengthinmenandwomenwithchronicillnessanevaluationofmoderatingandmediatinginfluences AT bourgoinvincent childhoodmaltreatmentandleukocytetelomerelengthinmenandwomenwithchronicillnessanevaluationofmoderatingandmediatinginfluences AT dubemariepierre childhoodmaltreatmentandleukocytetelomerelengthinmenandwomenwithchronicillnessanevaluationofmoderatingandmediatinginfluences AT busseuildavid childhoodmaltreatmentandleukocytetelomerelengthinmenandwomenwithchronicillnessanevaluationofmoderatingandmediatinginfluences AT dantonobianca childhoodmaltreatmentandleukocytetelomerelengthinmenandwomenwithchronicillnessanevaluationofmoderatingandmediatinginfluences |