Natural product P57 induces hypothermia through targeting pyridoxal kinase

Induction of hypothermia during hibernation/torpor enables certain mammals to survive under extreme environmental conditions. However, pharmacological induction of hypothermia in most mammals remains a huge challenge. Here we show that a natural product P57 promptly induces hypothermia and decreases...

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Detalles Bibliográficos
Autores principales: Wang, Ruina, Xiao, Lei, Pan, Jianbo, Bao, Guangsen, Zhu, Yunmei, Zhu, Di, Wang, Jun, Pei, Chengfeng, Ma, Qinfeng, Fu, Xian, Wang, Ziruoyu, Zhu, Mengdi, Wang, Guoxiang, Gong, Ling, Tong, Qiuping, Jiang, Min, Hu, Junchi, He, Miao, Wang, Yun, Li, Tiejun, Liang, Chunmin, Li, Wei, Xia, Chunmei, Li, Zengxia, Ma, Dengke K., Tan, Minjia, Liu, Jun Yan, Jiang, Wei, Luo, Cheng, Yu, Biao, Dang, Yongjun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10522591/
https://www.ncbi.nlm.nih.gov/pubmed/37752106
http://dx.doi.org/10.1038/s41467-023-41435-y

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