Low dosage combination treatment with metformin and simvastatin inhibits obesity-promoted pancreatic cancer development in male KrasG12D mice

Pancreatic ductal adenocarcinoma (PDAC), a highly lethal disease with limited therapeutic options, may benefit from repurposing of FDA-approved drugs in preventive or interceptive strategies in high-risk populations. Previous animal studies demonstrated that the use of metformin and statins as singl...

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Detalles Bibliográficos
Autores principales: Teper, Yaroslav, Ye, Linda, Waldron, Richard T., Lugea, Aurelia, Sun, Xiaoying, Sinnett-Smith, James, Hines, Oscar J., Pandol, Stephen J., Rozengurt, Enrique, Eibl, Guido
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10522691/
https://www.ncbi.nlm.nih.gov/pubmed/37752238
http://dx.doi.org/10.1038/s41598-023-43498-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10522691/
https://www.ncbi.nlm.nih.gov/pubmed/37752238
http://dx.doi.org/10.1038/s41598-023-43498-9

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