Cargando…

Low dosage combination treatment with metformin and simvastatin inhibits obesity-promoted pancreatic cancer development in male KrasG12D mice

Pancreatic ductal adenocarcinoma (PDAC), a highly lethal disease with limited therapeutic options, may benefit from repurposing of FDA-approved drugs in preventive or interceptive strategies in high-risk populations. Previous animal studies demonstrated that the use of metformin and statins as singl...

Descripción completa

Detalles Bibliográficos
Autores principales:	Teper, Yaroslav, Ye, Linda, Waldron, Richard T., Lugea, Aurelia, Sun, Xiaoying, Sinnett-Smith, James, Hines, Oscar J., Pandol, Stephen J., Rozengurt, Enrique, Eibl, Guido
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10522691/ https://www.ncbi.nlm.nih.gov/pubmed/37752238 http://dx.doi.org/10.1038/s41598-023-43498-9

Ejemplares similares

Incidence of pancreatic cancer is dramatically increased by a high fat, high calorie diet in KrasG12D mice
por: Chang, Hui-Hua, et al.
Publicado: (2017)

Metformin Decreases the Incidence of Pancreatic Ductal Adenocarcinoma Promoted by Diet-induced Obesity in the Conditional KrasG12D Mouse Model
por: Chang, Hui-Hua, et al.
Publicado: (2018)

Deficiency in hormone-sensitive lipase accelerates the development of pancreatic cancer in conditional KrasG12D mice
por: Xu, Mu, et al.
Publicado: (2018)

Statins Inhibit Inflammatory Cytokine Production by Macrophages and Acinar-to-Ductal Metaplasia of Pancreatic Cells
por: Ako, Soichiro, et al.
Publicado: (2022)

Opposite Effects of Src Family Kinases on YAP and ERK Activation in Pancreatic Cancer Cells: Implications for Targeted Therapy
por: Sinnett-Smith, James, et al.
Publicado: (2022)

Crosstalk between KRAS, SRC and YAP Signaling in Pancreatic Cancer: Interactions Leading to Aggressive Disease and Drug Resistance
por: Rozengurt, Enrique, et al.
Publicado: (2021)

Diabetes, pancreatic cancer, and metformin therapy
por: Gong, Jun, et al.
Publicado: (2014)

Yes-associated protein (YAP) in pancreatic cancer: at the epicenter of a targetable signaling network associated with patient survival
por: Rozengurt, Enrique, et al.
Publicado: (2018)

Pancreatic Adaptive Responses in Alcohol Abuse: Role of the Unfolded Protein Response
por: Lugea, Aurelia, et al.
Publicado: (2015)

Role and regulation of Yap in KrasG12D-induced lung cancer
por: Mao, Yaopan, et al.
Publicado: (2017)

Targeting oncogenic KRasG13C with nucleotide-based covalent inhibitors
por: Goebel, Lisa, et al.
Publicado: (2023)

Dose-Dependent AMPK-Dependent and Independent Mechanisms of Berberine and Metformin Inhibition of mTORC1, ERK, DNA Synthesis and Proliferation in Pancreatic Cancer Cells
por: Ming, Ming, et al.
Publicado: (2014)

Lipophilic statins inhibit YAP nuclear localization, co-activator activity and colony formation in pancreatic cancer cells and prevent the initial stages of pancreatic ductal adenocarcinoma in Kras(G12D) mice
por: Hao, Fang, et al.
Publicado: (2019)

Proteomic Identification of Novel Plasma Biomarkers and Pathobiologic Pathways in Alcoholic Acute Pancreatitis
por: Waldron, Richard T., et al.
Publicado: (2018)

KRasG12C inhibitors in clinical trials: a short historical perspective
por: Goebel, Lisa, et al.
Publicado: (2020)

Pancreatic Macrophages: Critical Players in Obesity-Promoted Pancreatic Cancer
por: Teper, Yaroslav, et al.
Publicado: (2020)

Central role of Yes-associated protein and WW-domain-containing transcriptional co-activator with PDZ-binding motif in pancreatic cancer development
por: Rozengurt, Enrique, et al.
Publicado: (2019)

Obesity and Pancreatic Cancer: Insight into Mechanisms
por: Eibl, Guido, et al.
Publicado: (2021)

Incidence of New Onset Diabetes Mellitus Secondary to Acute Pancreatitis: A Systematic Review and Meta-Analysis
por: Zhi, Mengmeng, et al.
Publicado: (2019)

Determination of Rottlerin, a Natural Protein Kinases C Inhibitor, in Pancreatic Cancer Cells and Mouse Xenografts by RP-HPLC Method
por: Lu, Qing-Yi, et al.
Publicado: (2012)

The Unfolded Protein Response Plays a Predominant Homeostatic Role in Response to Mitochondrial Stress in Pancreatic Stellate Cells
por: Su, Hsin-Yuan, et al.
Publicado: (2016)

Environmental and Genetic Stressors and the Unfolded Protein Response in Exocrine Pancreatic Function – A Hypothesis
por: Pandol, Stephen J., et al.
Publicado: (2011)

Addition of metabolomics to the omics spectrum for cancer biomarker development– demonstration with the KrasG12D mouse model for pancreatic carcinoma
por: Laiakis, Evagelia C, et al.
Publicado: (2014)

Different Patterns of Akt and ERK Feedback Activation in Response to Rapamycin, Active-Site mTOR Inhibitors and Metformin in Pancreatic Cancer Cells
por: Soares, Heloisa P., et al.
Publicado: (2013)

Molecular and Functional Characteristics of Ovarian Surface Epithelial Cells Transformed by KrasG12D and loss of Pten in a Mouse Model in vivo
por: Mullany, Lisa K., et al.
Publicado: (2011)

The Differential Role of Human Cationic Trypsinogen (PRSS1) p.R122H Mutation in Hereditary and Nonhereditary Chronic Pancreatitis: A Systematic Review and Meta-Analysis
por: Hu, Cheng, et al.
Publicado: (2017)

Yes-Associated Protein 1 Plays Major Roles in Pancreatic Stellate Cell Activation and Fibroinflammatory Responses
por: Hu, Cheng, et al.
Publicado: (2019)

Uniting Epidemiology and Experimental Disease Models for Alcohol-Related Pancreatic Disease
por: Setiawan, Veronica Wendy, et al.
Publicado: (2017)

Pathological Mechanisms in Diabetes of the Exocrine Pancreas: What’s Known and What’s to Know
por: Wei, Qiong, et al.
Publicado: (2020)

HMGA1 expression levels are elevated in pancreatic intraepithelial neoplasia cells in the Ptf1a-Cre; LSL-KrasG12D transgenic mouse model of pancreatic cancer
por: Veite-Schmahl, Michelle J, et al.
Publicado: (2017)

Effect of Metformin and Simvastatin in Inhibiting Proadipogenic Transcription Factors
por: Jakab, Jelena, et al.
Publicado: (2021)

PKD1 Mediates Negative Feedback of PI3K/Akt Activation in Response to G Protein-Coupled Receptors
por: Ni, Yang, et al.
Publicado: (2013)

Correction: PKD1 Mediates Negative Feedback of PI3K/Akt Activation in Response to G Protein-Coupled Receptors
por: Ni, Yang, et al.
Publicado: (2014)

Signature-driven repurposing of Midostaurin for combination with MEK1/2 and KRASG12C inhibitors in lung cancer
por: Macaya, Irati, et al.
Publicado: (2023)

The unique pancreatic stellate cell gene expression signatures are associated with the progression from acute to chronic pancreatitis
por: Hu, Cheng, et al.
Publicado: (2021)

Mass spectrometry quantifies target engagement for a KRASG12C inhibitor in FFPE tumor tissue
por: Chambers, Andrew G., et al.
Publicado: (2023)

Pathogenic Carboxyl Ester Lipase (CEL) Variants Interact with the Normal CEL Protein in Pancreatic Cells
por: Dalva, Monica, et al.
Publicado: (2020)

NMR-based metabolic profiling of urine, serum, fecal, and pancreatic tissue samples from the Ptf1a-Cre; LSL-KrasG12D transgenic mouse model of pancreatic cancer
por: Schmahl, Michelle J., et al.
Publicado: (2018)

Down-regulation of pancreatic and duodenal homeobox-1 by somatostatin receptor subtype 5: a novel mechanism for inhibition of cellular proliferation and insulin secretion by somatostatin
por: Zhou, Guisheng, et al.
Publicado: (2014)

Targeting the CBP/β-Catenin Interaction to Suppress Activation of Cancer-Promoting Pancreatic Stellate Cells
por: Che, Mingtian, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_0utoehrfh28hbfgastlfffknep