GLP-2 Improves Hepatic Inflammation and Fibrosis in Mdr2(-/-) Mice Via Activation of NR4a1/Nur77 in Hepatic Stellate Cells and Intestinal FXR Signaling

BACKGROUND & AIMS: Glucagon-like peptide (GLP)-2 may exert antifibrotic effects on hepatic stellate cells (HSCs). Thus, we aimed to test whether application of the GLP-2 analogue teduglutide has hepatoprotective and antifibrotic effects in the Mdr2/Abcb4(-/-) mouse model of sclerosing cholangiti...

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Detalles Bibliográficos
Autores principales: Fuchs, Claudia D., Claudel, Thierry, Mlitz, Veronika, Riva, Alessandra, Menz, Moritz, Brusilovskaya, Ksenia, Haller, Felix, Baumgartner, Maximilian, Königshofer, Philipp, Unger, Lukas W., Sjöland, Wilhelm, Scharnagl, Hubert, Stojakovic, Tatjana, Busslinger, Georg, Reiberger, Thomas, Marschall, Hanns-Ulrich, Trauner, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10522987/
https://www.ncbi.nlm.nih.gov/pubmed/37572734
http://dx.doi.org/10.1016/j.jcmgh.2023.08.003

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