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The interplay of inflammation and remodeling in the pathogenesis of chronic rhinosinusitis: current understanding and future directions

Chronic rhinosinusitis (CRS), a common clinical condition characterized by persistent mucosal inflammation and tissue remodeling, has a complex pathogenesis that is intricately linked to innate and adaptive immunity. A number of studies have demonstrated that a variety of immune cells and cytokines...

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Autores principales: Gong, Xinru, Han, Zhoutong, Fan, Hongli, Wu, Yuqi, He, Yuanqiong, Fu, Yijie, Zhu, Tianmin, Li, Hui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10523020/
https://www.ncbi.nlm.nih.gov/pubmed/37771597
http://dx.doi.org/10.3389/fimmu.2023.1238673
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author Gong, Xinru
Han, Zhoutong
Fan, Hongli
Wu, Yuqi
He, Yuanqiong
Fu, Yijie
Zhu, Tianmin
Li, Hui
author_facet Gong, Xinru
Han, Zhoutong
Fan, Hongli
Wu, Yuqi
He, Yuanqiong
Fu, Yijie
Zhu, Tianmin
Li, Hui
author_sort Gong, Xinru
collection PubMed
description Chronic rhinosinusitis (CRS), a common clinical condition characterized by persistent mucosal inflammation and tissue remodeling, has a complex pathogenesis that is intricately linked to innate and adaptive immunity. A number of studies have demonstrated that a variety of immune cells and cytokines that play a vital role in mediating inflammation in CRS are also involved in remodeling of the nasal mucosa and the cells as well as different cytokines involved in remodeling in CRS are also able to exert some influence on inflammation, even though the exact relationship between inflammation and remodeling in CRS has not yet been fully elucidated. In this review, the potential role of immune cells and cytokines in regulating inflammation and remodeling of CRS mucosa has been described, starting with the immune cells and cytokines that act together in inflammation and remodeling. The goal is to aid researchers in understanding intimate connection between inflammation and remodeling of CRS and to offer novel ideas for future research.
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spelling pubmed-105230202023-09-28 The interplay of inflammation and remodeling in the pathogenesis of chronic rhinosinusitis: current understanding and future directions Gong, Xinru Han, Zhoutong Fan, Hongli Wu, Yuqi He, Yuanqiong Fu, Yijie Zhu, Tianmin Li, Hui Front Immunol Immunology Chronic rhinosinusitis (CRS), a common clinical condition characterized by persistent mucosal inflammation and tissue remodeling, has a complex pathogenesis that is intricately linked to innate and adaptive immunity. A number of studies have demonstrated that a variety of immune cells and cytokines that play a vital role in mediating inflammation in CRS are also involved in remodeling of the nasal mucosa and the cells as well as different cytokines involved in remodeling in CRS are also able to exert some influence on inflammation, even though the exact relationship between inflammation and remodeling in CRS has not yet been fully elucidated. In this review, the potential role of immune cells and cytokines in regulating inflammation and remodeling of CRS mucosa has been described, starting with the immune cells and cytokines that act together in inflammation and remodeling. The goal is to aid researchers in understanding intimate connection between inflammation and remodeling of CRS and to offer novel ideas for future research. Frontiers Media S.A. 2023-09-12 /pmc/articles/PMC10523020/ /pubmed/37771597 http://dx.doi.org/10.3389/fimmu.2023.1238673 Text en Copyright © 2023 Gong, Han, Fan, Wu, He, Fu, Zhu and Li https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Gong, Xinru
Han, Zhoutong
Fan, Hongli
Wu, Yuqi
He, Yuanqiong
Fu, Yijie
Zhu, Tianmin
Li, Hui
The interplay of inflammation and remodeling in the pathogenesis of chronic rhinosinusitis: current understanding and future directions
title The interplay of inflammation and remodeling in the pathogenesis of chronic rhinosinusitis: current understanding and future directions
title_full The interplay of inflammation and remodeling in the pathogenesis of chronic rhinosinusitis: current understanding and future directions
title_fullStr The interplay of inflammation and remodeling in the pathogenesis of chronic rhinosinusitis: current understanding and future directions
title_full_unstemmed The interplay of inflammation and remodeling in the pathogenesis of chronic rhinosinusitis: current understanding and future directions
title_short The interplay of inflammation and remodeling in the pathogenesis of chronic rhinosinusitis: current understanding and future directions
title_sort interplay of inflammation and remodeling in the pathogenesis of chronic rhinosinusitis: current understanding and future directions
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10523020/
https://www.ncbi.nlm.nih.gov/pubmed/37771597
http://dx.doi.org/10.3389/fimmu.2023.1238673
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