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The interplay of inflammation and remodeling in the pathogenesis of chronic rhinosinusitis: current understanding and future directions
Chronic rhinosinusitis (CRS), a common clinical condition characterized by persistent mucosal inflammation and tissue remodeling, has a complex pathogenesis that is intricately linked to innate and adaptive immunity. A number of studies have demonstrated that a variety of immune cells and cytokines...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10523020/ https://www.ncbi.nlm.nih.gov/pubmed/37771597 http://dx.doi.org/10.3389/fimmu.2023.1238673 |
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author | Gong, Xinru Han, Zhoutong Fan, Hongli Wu, Yuqi He, Yuanqiong Fu, Yijie Zhu, Tianmin Li, Hui |
author_facet | Gong, Xinru Han, Zhoutong Fan, Hongli Wu, Yuqi He, Yuanqiong Fu, Yijie Zhu, Tianmin Li, Hui |
author_sort | Gong, Xinru |
collection | PubMed |
description | Chronic rhinosinusitis (CRS), a common clinical condition characterized by persistent mucosal inflammation and tissue remodeling, has a complex pathogenesis that is intricately linked to innate and adaptive immunity. A number of studies have demonstrated that a variety of immune cells and cytokines that play a vital role in mediating inflammation in CRS are also involved in remodeling of the nasal mucosa and the cells as well as different cytokines involved in remodeling in CRS are also able to exert some influence on inflammation, even though the exact relationship between inflammation and remodeling in CRS has not yet been fully elucidated. In this review, the potential role of immune cells and cytokines in regulating inflammation and remodeling of CRS mucosa has been described, starting with the immune cells and cytokines that act together in inflammation and remodeling. The goal is to aid researchers in understanding intimate connection between inflammation and remodeling of CRS and to offer novel ideas for future research. |
format | Online Article Text |
id | pubmed-10523020 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-105230202023-09-28 The interplay of inflammation and remodeling in the pathogenesis of chronic rhinosinusitis: current understanding and future directions Gong, Xinru Han, Zhoutong Fan, Hongli Wu, Yuqi He, Yuanqiong Fu, Yijie Zhu, Tianmin Li, Hui Front Immunol Immunology Chronic rhinosinusitis (CRS), a common clinical condition characterized by persistent mucosal inflammation and tissue remodeling, has a complex pathogenesis that is intricately linked to innate and adaptive immunity. A number of studies have demonstrated that a variety of immune cells and cytokines that play a vital role in mediating inflammation in CRS are also involved in remodeling of the nasal mucosa and the cells as well as different cytokines involved in remodeling in CRS are also able to exert some influence on inflammation, even though the exact relationship between inflammation and remodeling in CRS has not yet been fully elucidated. In this review, the potential role of immune cells and cytokines in regulating inflammation and remodeling of CRS mucosa has been described, starting with the immune cells and cytokines that act together in inflammation and remodeling. The goal is to aid researchers in understanding intimate connection between inflammation and remodeling of CRS and to offer novel ideas for future research. Frontiers Media S.A. 2023-09-12 /pmc/articles/PMC10523020/ /pubmed/37771597 http://dx.doi.org/10.3389/fimmu.2023.1238673 Text en Copyright © 2023 Gong, Han, Fan, Wu, He, Fu, Zhu and Li https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology Gong, Xinru Han, Zhoutong Fan, Hongli Wu, Yuqi He, Yuanqiong Fu, Yijie Zhu, Tianmin Li, Hui The interplay of inflammation and remodeling in the pathogenesis of chronic rhinosinusitis: current understanding and future directions |
title | The interplay of inflammation and remodeling in the pathogenesis of chronic rhinosinusitis: current understanding and future directions |
title_full | The interplay of inflammation and remodeling in the pathogenesis of chronic rhinosinusitis: current understanding and future directions |
title_fullStr | The interplay of inflammation and remodeling in the pathogenesis of chronic rhinosinusitis: current understanding and future directions |
title_full_unstemmed | The interplay of inflammation and remodeling in the pathogenesis of chronic rhinosinusitis: current understanding and future directions |
title_short | The interplay of inflammation and remodeling in the pathogenesis of chronic rhinosinusitis: current understanding and future directions |
title_sort | interplay of inflammation and remodeling in the pathogenesis of chronic rhinosinusitis: current understanding and future directions |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10523020/ https://www.ncbi.nlm.nih.gov/pubmed/37771597 http://dx.doi.org/10.3389/fimmu.2023.1238673 |
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