Design, synthesis and biological evaluation of VEGFR-2/HDAC dual inhibitors as multitargeted antitumor agents based on fruquintinib and vorinostat

Herein, a series of 4-(benzofuran-6-yloxy)quinazoline derivatives as VEGFR-2/HDAC dual inhibitors were designed and synthesized based on fruquintinib and vorinostat. Among them, compound 13 exhibited potent inhibitory activity against VEGFR-2 and HDAC1 with IC(50) values of 57.83 nM and 9.82 nM, and...

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Detalles Bibliográficos
Autores principales: Gao, Yali, Li, Fei, Ni, Xin, Yang, Siwang, Liu, Han, Wu, Xingye, Liu, Jieqing, Ma, Junjie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2023
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10523135/
https://www.ncbi.nlm.nih.gov/pubmed/37771923
http://dx.doi.org/10.1039/d3ra05542f

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