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From acute abdomen to hormonal crisis: Case report on a long-delayed Sheehan's syndrome diagnosis

INTRODUCTION: Sheehan's syndrome (SS) is a rare cause of hypopituitarism resulting from postpartum haemorrhage and pituitary necrosis. It remains an underdiagnosed condition, especially in developing countries due to poor obstetric care and home deliveries. This case report highlights the signi...

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Autores principales: Adil, Maham Leeza, Alvi, Mahrukh, Khan, Aqsa, Qaiser, Shan Mohammad Mustafa, Osman, Muhammad, Bashir, Muhammad Nauman
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10523179/
https://www.ncbi.nlm.nih.gov/pubmed/37738831
http://dx.doi.org/10.1016/j.ijscr.2023.108831
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author Adil, Maham Leeza
Alvi, Mahrukh
Khan, Aqsa
Qaiser, Shan Mohammad Mustafa
Osman, Muhammad
Bashir, Muhammad Nauman
author_facet Adil, Maham Leeza
Alvi, Mahrukh
Khan, Aqsa
Qaiser, Shan Mohammad Mustafa
Osman, Muhammad
Bashir, Muhammad Nauman
author_sort Adil, Maham Leeza
collection PubMed
description INTRODUCTION: Sheehan's syndrome (SS) is a rare cause of hypopituitarism resulting from postpartum haemorrhage and pituitary necrosis. It remains an underdiagnosed condition, especially in developing countries due to poor obstetric care and home deliveries. This case report highlights the significance of recognizing atypical presentations of SS, such as pancytopenia, to aid in early diagnosis and management. CASE PRESENTATION: A 40-year-old female presented with acute abdomen symptoms and was initially diagnosed with acalculous cholecystitis. However, a detailed history revealed a history of postpartum haemorrhage 18 years prior, leading to a provisional diagnosis of SS. Further investigations confirmed panhypopituitarism, including hypothyroidism, hypocortisolism, and hypogonadism. Notably, the patient also exhibited pancytopenia, a rarely reported haematological manifestation of SS. DISCUSSION: SS often presents with nonspecific symptoms, leading to delayed or missed diagnoses. In this case, the patient's initial presentation of acute abdomen symptoms was attributed to secondary adrenal insufficiency due to panhypopituitarism. The presence of pancytopenia, along with hyponatremia, further complicated the clinical picture. Hormone replacement therapy led to a remarkable improvement in the patient's condition, emphasizing the importance of early diagnosis and intervention. CONCLUSION: SS is a common cause of panhypopituitarism in developing countries, but its atypical presentations, such as pancytopenia, are rare and often overlooked. This case highlights the need for increased awareness among clinicians to consider SS in patients with unexplained haematological abnormalities, particularly in regions with high rates of postpartum haemorrhage. Early recognition and appropriate hormone replacement therapy can significantly improve patients' outcomes and prevent long-term complications associated with this underdiagnosed syndrome.
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spelling pubmed-105231792023-09-28 From acute abdomen to hormonal crisis: Case report on a long-delayed Sheehan's syndrome diagnosis Adil, Maham Leeza Alvi, Mahrukh Khan, Aqsa Qaiser, Shan Mohammad Mustafa Osman, Muhammad Bashir, Muhammad Nauman Int J Surg Case Rep Case Report INTRODUCTION: Sheehan's syndrome (SS) is a rare cause of hypopituitarism resulting from postpartum haemorrhage and pituitary necrosis. It remains an underdiagnosed condition, especially in developing countries due to poor obstetric care and home deliveries. This case report highlights the significance of recognizing atypical presentations of SS, such as pancytopenia, to aid in early diagnosis and management. CASE PRESENTATION: A 40-year-old female presented with acute abdomen symptoms and was initially diagnosed with acalculous cholecystitis. However, a detailed history revealed a history of postpartum haemorrhage 18 years prior, leading to a provisional diagnosis of SS. Further investigations confirmed panhypopituitarism, including hypothyroidism, hypocortisolism, and hypogonadism. Notably, the patient also exhibited pancytopenia, a rarely reported haematological manifestation of SS. DISCUSSION: SS often presents with nonspecific symptoms, leading to delayed or missed diagnoses. In this case, the patient's initial presentation of acute abdomen symptoms was attributed to secondary adrenal insufficiency due to panhypopituitarism. The presence of pancytopenia, along with hyponatremia, further complicated the clinical picture. Hormone replacement therapy led to a remarkable improvement in the patient's condition, emphasizing the importance of early diagnosis and intervention. CONCLUSION: SS is a common cause of panhypopituitarism in developing countries, but its atypical presentations, such as pancytopenia, are rare and often overlooked. This case highlights the need for increased awareness among clinicians to consider SS in patients with unexplained haematological abnormalities, particularly in regions with high rates of postpartum haemorrhage. Early recognition and appropriate hormone replacement therapy can significantly improve patients' outcomes and prevent long-term complications associated with this underdiagnosed syndrome. Elsevier 2023-09-16 /pmc/articles/PMC10523179/ /pubmed/37738831 http://dx.doi.org/10.1016/j.ijscr.2023.108831 Text en © 2023 The Author(s) https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Adil, Maham Leeza
Alvi, Mahrukh
Khan, Aqsa
Qaiser, Shan Mohammad Mustafa
Osman, Muhammad
Bashir, Muhammad Nauman
From acute abdomen to hormonal crisis: Case report on a long-delayed Sheehan's syndrome diagnosis
title From acute abdomen to hormonal crisis: Case report on a long-delayed Sheehan's syndrome diagnosis
title_full From acute abdomen to hormonal crisis: Case report on a long-delayed Sheehan's syndrome diagnosis
title_fullStr From acute abdomen to hormonal crisis: Case report on a long-delayed Sheehan's syndrome diagnosis
title_full_unstemmed From acute abdomen to hormonal crisis: Case report on a long-delayed Sheehan's syndrome diagnosis
title_short From acute abdomen to hormonal crisis: Case report on a long-delayed Sheehan's syndrome diagnosis
title_sort from acute abdomen to hormonal crisis: case report on a long-delayed sheehan's syndrome diagnosis
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10523179/
https://www.ncbi.nlm.nih.gov/pubmed/37738831
http://dx.doi.org/10.1016/j.ijscr.2023.108831
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