The smallest functional antibody fragment: Ultralong CDR H3 antibody knob regions potently neutralize SARS-CoV-2

Cows produce antibodies with a disulfide-bonded antigen-binding domain embedded within ultralong heavy chain third complementarity determining regions. This “knob” domain is analogous to natural cysteine-rich peptides such as knottins in that it is small and stable but can accommodate diverse loops...

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Detalles Bibliográficos
Autores principales: Huang, Ruiqi, Warner Jenkins, Gabrielle, Kim, Yunjeong, Stanfield, Robyn L., Singh, Amrinder, Martinez-Yamout, Maria, Kroon, Gerard J., Torres, Jonathan L., Jackson, Abigail M., Kelley, Abigail, Shaabani, Namir, Zeng, Baisen, Bacica, Michael, Chen, Wen, Warner, Christopher, Radoicic, Jasmina, Joh, Joongho, Dinali Perera, Krishani, Sang, Huldah, Kim, Tae, Yao, Jianxiu, Zhao, Fangzhu, Sok, Devin, Burton, Dennis R., Allen, Jeff, Harriman, William, Mwangi, Waithaka, Chung, Donghoon, Teijaro, John R., Ward, Andrew B., Dyson, H. Jane, Wright, Peter E., Wilson, Ian A., Chang, Kyeong-Ok, McGregor, Duncan, Smider, Vaughn V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2023
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10523490/
https://www.ncbi.nlm.nih.gov/pubmed/37722054
http://dx.doi.org/10.1073/pnas.2303455120

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