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Obstructive sleep apnea: a major risk factor for COVID-19 encephalopathy?
BACKGROUND: This study evaluates the impact of high risk of obstructive sleep apnea (OSA) on coronavirus disease 2019 (COVID-19) acute encephalopathy (AE). METHODS: Between 3/1/2020 and 11/1/2021, 97 consecutive patients were evaluated at the Geneva University Hospitals with a neurological diagnosis...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10523731/ https://www.ncbi.nlm.nih.gov/pubmed/37752429 http://dx.doi.org/10.1186/s12883-023-03393-2 |
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author | Breville, Gautier Herrmann, François Adler, Dan Deffert, Christine Bommarito, Giulia Stancu, Patrick Accorroni, Alice Uginet, Marjolaine Assal, Frederic Tamisier, Renaud Lalive, Patrice H. Pepin, Jean-Louis Lövblad, Karl-Olof Allali, Gilles |
author_facet | Breville, Gautier Herrmann, François Adler, Dan Deffert, Christine Bommarito, Giulia Stancu, Patrick Accorroni, Alice Uginet, Marjolaine Assal, Frederic Tamisier, Renaud Lalive, Patrice H. Pepin, Jean-Louis Lövblad, Karl-Olof Allali, Gilles |
author_sort | Breville, Gautier |
collection | PubMed |
description | BACKGROUND: This study evaluates the impact of high risk of obstructive sleep apnea (OSA) on coronavirus disease 2019 (COVID-19) acute encephalopathy (AE). METHODS: Between 3/1/2020 and 11/1/2021, 97 consecutive patients were evaluated at the Geneva University Hospitals with a neurological diagnosis of COVID-19 AE. They were divided in two groups depending on the presence or absence of high risk for OSA based on the modified NOSAS score (mNOSAS, respectively ≥ 8 and < 8). We compared patients’ characteristics (clinical, biological, brain MRI, EEG, pulmonary CT). The severity of COVID-19 AE relied on the RASS and CAM scores. RESULTS: Most COVID-19 AE patients presented with a high mNOSAS, suggesting high risk of OSA (> 80%). Patients with a high mNOSAS had a more severe form of COVID-19 AE (84.8% versus 27.8%), longer mean duration of COVID-19 AE (27.9 versus 16.9 days), higher mRS at discharge (≥ 3 in 58.2% versus 16.7%), and increased prevalence of brain vessels enhancement (98.1% versus 20.0%). High risk of OSA was associated with a 14 fold increased risk of developing a severe COVID-19 AE (OR = 14.52). DISCUSSION: These observations suggest an association between high risk of OSA and COVID-19 AE severity. High risk of OSA could be a predisposing factor leading to severe COVID-19 AE and consecutive long-term sequalae. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12883-023-03393-2. |
format | Online Article Text |
id | pubmed-10523731 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-105237312023-09-28 Obstructive sleep apnea: a major risk factor for COVID-19 encephalopathy? Breville, Gautier Herrmann, François Adler, Dan Deffert, Christine Bommarito, Giulia Stancu, Patrick Accorroni, Alice Uginet, Marjolaine Assal, Frederic Tamisier, Renaud Lalive, Patrice H. Pepin, Jean-Louis Lövblad, Karl-Olof Allali, Gilles BMC Neurol Research BACKGROUND: This study evaluates the impact of high risk of obstructive sleep apnea (OSA) on coronavirus disease 2019 (COVID-19) acute encephalopathy (AE). METHODS: Between 3/1/2020 and 11/1/2021, 97 consecutive patients were evaluated at the Geneva University Hospitals with a neurological diagnosis of COVID-19 AE. They were divided in two groups depending on the presence or absence of high risk for OSA based on the modified NOSAS score (mNOSAS, respectively ≥ 8 and < 8). We compared patients’ characteristics (clinical, biological, brain MRI, EEG, pulmonary CT). The severity of COVID-19 AE relied on the RASS and CAM scores. RESULTS: Most COVID-19 AE patients presented with a high mNOSAS, suggesting high risk of OSA (> 80%). Patients with a high mNOSAS had a more severe form of COVID-19 AE (84.8% versus 27.8%), longer mean duration of COVID-19 AE (27.9 versus 16.9 days), higher mRS at discharge (≥ 3 in 58.2% versus 16.7%), and increased prevalence of brain vessels enhancement (98.1% versus 20.0%). High risk of OSA was associated with a 14 fold increased risk of developing a severe COVID-19 AE (OR = 14.52). DISCUSSION: These observations suggest an association between high risk of OSA and COVID-19 AE severity. High risk of OSA could be a predisposing factor leading to severe COVID-19 AE and consecutive long-term sequalae. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12883-023-03393-2. BioMed Central 2023-09-27 /pmc/articles/PMC10523731/ /pubmed/37752429 http://dx.doi.org/10.1186/s12883-023-03393-2 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research Breville, Gautier Herrmann, François Adler, Dan Deffert, Christine Bommarito, Giulia Stancu, Patrick Accorroni, Alice Uginet, Marjolaine Assal, Frederic Tamisier, Renaud Lalive, Patrice H. Pepin, Jean-Louis Lövblad, Karl-Olof Allali, Gilles Obstructive sleep apnea: a major risk factor for COVID-19 encephalopathy? |
title | Obstructive sleep apnea: a major risk factor for COVID-19 encephalopathy? |
title_full | Obstructive sleep apnea: a major risk factor for COVID-19 encephalopathy? |
title_fullStr | Obstructive sleep apnea: a major risk factor for COVID-19 encephalopathy? |
title_full_unstemmed | Obstructive sleep apnea: a major risk factor for COVID-19 encephalopathy? |
title_short | Obstructive sleep apnea: a major risk factor for COVID-19 encephalopathy? |
title_sort | obstructive sleep apnea: a major risk factor for covid-19 encephalopathy? |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10523731/ https://www.ncbi.nlm.nih.gov/pubmed/37752429 http://dx.doi.org/10.1186/s12883-023-03393-2 |
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